2. Antibody-drug Conjugate/ADC Related PROTAC
  3. ADC Linker PROTAC Linkers
  4. Ethyl azetidine-3-carboxylate hydrochloride

Ethyl azetidine-3-carboxylate hydrochloride  (Synonyms: 氮杂丁烷-3-羧酸乙酯盐酸盐)

目录号: HY-W052600 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

Ethyl azetidine-3-carboxylate hydrochloride 是不可降解 (non-cleavable) 的 ADC linker，用于合成抗体偶联活性分子 (ADCs)。Ethyl azetidine-3-carboxylate hydrochloride 也是一个基于烷基链 (alkyl chain) 的 PROTAC linker，可用于合成 PROTAC。

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Ethyl azetidine-3-carboxylate hydrochloride Chemical Structure

Ethyl azetidine-3-carboxylate hydrochloride Chemical Structure

CAS No. : 405090-31-5

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规格 价格 是否有货 数量
5 g ￥150
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10 g ￥235
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25 g ￥578
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Ethyl azetidine-3-carboxylate hydrochloride 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ethyl azetidine-3-carboxylate hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Ethyl azetidine-3-carboxylate hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2]

IC50 & Target

Non-cleavable Linker

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ethyl azetidine-3-carboxylate hydrochloride 相关抗体:
分子量

165.62

Formula

C6H12ClNO2
CAS 号
性状

固体

颜色

White to off-white

中文名称

氮杂丁烷-3-羧酸乙酯盐酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥98.0%

COA (258 KB) HNMR (133 KB)

产品使用指南 (1538 KB)
参考文献

Ethyl azetidine-3-carboxylate hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ethyl azetidine-3-carboxylate405090-31-5氮杂丁烷-3-羧酸乙酯盐酸盐ADC LinkerPROTAC LinkersAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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目录号：
HY-W052600
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