2. Apoptosis Autophagy Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Apoptosis Autophagy Reactive Oxygen Species
  4. Fascaplysin

Fascaplysin 是一种抗微生物和细胞毒性的红色素，可来自海洋海绵 Fascaplysinopsis sp.。Fascaplysin 是以吲哚为原料，经7步合成的(得率 65%)。Fascaplysin 可诱导人白血病 HL-60 细胞凋亡和自噬。Fascaplysin 具有抗肿瘤活性。

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Fascaplysin Chemical Structure

Fascaplysin Chemical Structure

CAS No. : 114719-57-2

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规格 价格 是否有货
5 mg ￥4086
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Fascaplysin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Fascaplysin is an antimicrobial and cytotoxic red pigment, that can come from the marine sponge (Fascaplysinopsis sp.). Fascaplysin has been synthesized in seven steps from indole (65% yield). Fascaplysin can induces apoptosis and autophagy in human leukemia HL-60 cells. Fascaplysin shows anti-tumor activity[1][2].

体外研究
(In Vitro)

Fascaplysin induces autophagy as a cytoprotective response via ROS and p8 in vascular endothelial cells (VECs)[2].
Fascaplysin targets metabolic activity of the prostate cancer cells, without disrupting cell membrane's integrity[2].
. Fascaplysin induces caspase mediated crosstalk between apoptosis and autophagy through the inhibition of PI3K/AKT/mTOR signaling cascade in human leukemia HL-60 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Fascaplysin 相关抗体:
体内研究
(In Vivo)

Fascaplysin suppresses the growth of S180 cell-implanted tumors in vivo[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

306.75

Formula

C18H11ClN2O
CAS 号
结构分类
初始来源

sponge
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Fascaplysin 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fascaplysin114719-57-2ApoptosisAutophagyReactive Oxygen SpeciesS180 cellHL-60 cellsVascular endothelial cells (VECs)LeukemiaAnti-tumor activityInhibitorinhibitorinhibit

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目录号：
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