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  3. Felbamate hydrate

Felbamate hydrate  (Synonyms: W-554 hydrate; ADD-03055 hydrate)

目录号: HY-B0184A
产品使用指南

Felbamate hydrate (W-554 hydrate) 是非镇静性抗痉挛剂,活性与NMDA受体相关。

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Felbamate hydrate Chemical Structure

Felbamate hydrate Chemical Structure

CAS No. : 1177501-39-1

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Felbamate hydrate 的其他形式现货产品:

Other Forms of Felbamate hydrate:

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  • 生物活性

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生物活性

Felbamate hydrate (W-554 hydrate) is a potent nonsedative anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA) .

IC50 & Target

NMDA Receptor[1].

体外研究
(In Vitro)

Felbamate hydrate (W-554 hydrate) is an anti-epileptic drug used in the treatment of epilepsy. It is used to treat partial seizures (with and without generalization) in adults and partial and generalized seizures associated with Lennox-Gastaut syndrome in children. However, an increased risk of potentially fatal aplastic anemia and/or liver failure limit the drugs usage to severe refractory epilepsy[1]. Felbamate (W-554) has been proposed to a unique dual mechanism of action as a positive modulator of GABAA receptors and as a blocker of NMDA receptors, particularly isoforms containing the NR2B subunit. Although it is clear that felbamate does cause pharmacological inhibition of NMDA receptor of relevance of NMDA receptor blockade as a strategy for the treatment of human epilepsy has been questioned. Therefore, the importance of the effects of felbamate on NMDA receptors to its therapeutic action in epilepsy is uncertain[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
分子量

256.26

Formula

C11H16N2O5

CAS 号
中文名称

非尔氨酯水合物

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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