Felypressin acetate  (Synonyms: PLV-2 acetate)

Felypressin acetate (PLV-2 acetate) is a non-catecholamine vasoconstrictor and a vasopressin 1 agonist. Felypressin acetate is widely used in dental procedures^[1][2].

Vasopressin 1^[2]

Felypressin is a synthetic hormone of the posterior pituitary lobe characterized by vasoconstrictor properties that is widely used in dental procedures. The vasoconstrictor action of Felypressin seems to be mediated by V1 receptors of the blood vessel smooth muscle cells^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Felypressin can reduce toxicity during dental procedures. Felypressin increases the diastolic blood pressure of hypertensive patients with controlled blood pressure^[1].
Cardiovascular effects of Felypressin (240 ng/kg; intravenous injection) are studied in Wistar rats. Felypressin induces a pressor effect. Felypressin depends on V1 receptors to induce pressor and bradycardic effects, and that it produces a high relationship between bradycardia and mean arterial pressure variation depending on area postrema and central V1 receptors^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

C₄₆H₆₅N₁₃O₁₁S₂.xC₂H₄O₂

914453-97-7

固体

White to off-white

Cys-Phe-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 (Disulfide bridge: Cys1-Cys6)

CFFQNCPKG-NH2 (Disulfide bridge: Cys1-Cys6)

醋酸苯赖加压素

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Bronzo AL et al. Felypressin increases blood pressure during dental procedures in hypertensive patients. Arq Bras Cardiol. 2012 Aug;99(2):724-31.  [Content Brief]

  [2]. Cecanho R et al. Cardiovascular effects of felypressin. Anesth Prog. 2006 Winter;53(4):119-25.  [Content Brief]