1. Anti-infection
  2. Dengue virus Flavivirus HCV HIV
  3. FGI-106

FGI-106 是一种有效的广谱抑制剂,对多种病毒具有抑制活性。FGI-106 具有抗埃博拉病毒 (EBOV),裂谷病毒 (Rift Valley virus) 和登革热病毒 (Dengue Fever virus) 的活性,其 EC50 分别为 100 nM,800 nM 和 400-900 nM。FGI-106 还分别以 EC50 值为 200 nM 和 150 nM 抑制非失血性发热病毒 HCVHIV-1

在相同的摩尔浓度下,化合物盐形式与游离形式有相同的生物活性,但盐形式 FGI-106 tetrahydrochloride 通常具有更好的水溶性和稳定性。

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FGI-106 Chemical Structure

FGI-106 Chemical Structure

CAS No. : 501081-38-5

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FGI-106 is a potent and broad-spectrum inhibitor with inhibitory activity against multiple viruses. FGI-106 is active against Ebola, Rift Valley and Dengue Fever viruses with EC50s of 100 nM, 800 nM and 400-900 nM, respectively. FGI-106 also inhibits non-hemorrhagic fever viruses HCV and HIV-1 with EC50s of 200 nM and 150 nM, respectively[1].

IC50 & Target

HIV-1

 

体外研究
(In Vitro)

Treatment with 2 μM FGI-106 mediated a 4 log reduction in infectious viral titers relative to matched controls, with an EC90 for inhibition of viral killing of host cells (Vero E6 cells) estimated to be 0.6 μM[1].
In cell-based assays, treatment with FGI-106 inhibits viral replication by divergent virus families, including positive and negative-strand RNA viruses[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

FGI-106 (0.1-5 mg/kg; intraperitoneal injection; treatments on days 2 and 5; C57BL/6 or BALB/c mice) treatment decreases mortality from Zaire EBOV in a dose-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male or female C57BL/6 or BALB/c mice (6-10 weeks of age) injected with EBOV (Ebola virus)[1]
Dosage: 0.1 mg/kg, 0.5 mg/kg, 1 mg/kg, 2 mg/kg, 5 mg/kg
Administration: Intraperitoneal injection; treatments on days 2 and 5
Result: Decreased mortality from Zaire EBOV in a dose-dependent manner.
分子量

458.64

Formula

C28H38N6

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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FGI-106
目录号:
HY-124618
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