2. Protein Tyrosine Kinase/RTK
  3. IGF-1R
  4. Figitumumab

Figitumumab  (Synonyms: CP-751871)

目录号: HY-P99197 纯度: 96.89%
COA

摩尔计算器

Figitumumab (CP-751871) 是一种有效的全人抗胰岛素样生长因子 1 受体 (IGF1R) 单克隆抗体。Figitumumab 可阻止 IGF1 与 IGF1R 结合，IC50 为 1.8 nM。

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Figitumumab Chemical Structure

Figitumumab Chemical Structure

CAS No. : 943453-46-1

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Figitumumab 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Figitumumab (CP-751871) is a potent and fully human monoclonal anti–insulin-like growth factor 1 receptor (IGF1R) antibody. Figitumumab prevents IGF1 from binding to IGF1R with an IC50 of 1.8 nM[1].

IC50 & Target

IC50: 1.8 nM (IGF1R)[1]
体外研究
(In Vitro)

Figitumumab (CP-751871) (152 pM-10 μM; 3 days) inhibits cancer cell proliferation[1].
Figitumumab (1 μg/mL; 1 min or 24 h) induces the down-regulation of IGF-1R[2].
Figitumumab inhibits IGF1-induced autophosphorylation of IGF1R with an IC50 of 0.42 nM, and indirectly inhibits AKT activation[2].
Figitumumab recognizes the IGF-1R/IR heterodimer complex[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Figitumumab 相关抗体:

Cell Proliferation Assay[1]

Cell Line: Breast, colon, lung small cell, and non–small cell cancer lines
Concentration: 152 pM-10 μM
Incubation Time: 3 days
Result: 15 cell lines (NCIH441, NCIH526, SW403, CACO2, SW48, NCIH524, SKCO1, SNUC1, LS1034, COLO205, MDAMB361, NCIH508, LS513, MCF7, NCIH378) were highly sensitive to the drug at IC50 values ≦ 100 nM.

Western Blot Analysis[2]

Cell Line: 3T3/IGF-1R cell
Concentration: 1 μg/mL
Incubation Time: 1 min or 24 h
Result: Blocked IGF-I- or IGF-II-induced autophosphorylation of the IGF-1R.
体内研究
(In Vivo)

Figitumumab (CP-751871) (31-125 μg/mouse; i.p.; once) induces the down-regulation of tumor associated IGF-1R in mice[2].
Figitumumab (62.5-500 μg/mouse; i.p.; once) inhibits the growth of s.c. xenografts derived from colon (Colo-205), breast (MCF7), and lung (H460) cancer cell lines in mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female athymic mice (CD-1 nu/nu) bearing NIH3T3/IGF-1R tumors[2]
Dosage: 31 to 125 μg per mouse
Administration: Intraperitoneal injection, once
Result: Resulted in a serum Cmax between 12 and 24 hours. At 24 hours, there was a dose-dependent reduction of IGF-1R protein in tumors, with 50% reduction observed at a serum concentration of 15 μg/mL. Resulted in a down-regulation of IGF-1R from the tumor. The half-life in an athymic mouse was determined to be 4 to 6 days by longer-term studies.
Animal Model: Female athymic mice (CD-1 nu/nu), human Colo-205 tumor xenograft model[2]
Dosage: 62.5 μg or 250 μg per mouse
Administration: Intraperitoneal injection, once
Result: Inhibited the tumor growth.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

芬妥木单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Figitumumab 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Figitumumab943453-46-1CP-751871芬妥木单抗CP751871CP 751871IGF-1RInsulin-like growth factor-1 receptorIGF1IGF1RantitumorColo-205MCF7H460Inhibitorinhibitorinhibit

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