2. Immunology/Inflammation
  3. CD3
  4. Forimtamig

Forimtamig  (Synonyms: RG-6234; RO-7425781)

目录号: HY-P991055 纯度: 99.96%
COA 技术支持

Forimtamig (RG-6324) 是一种 GPRC5DxCD3 T 细胞结合双特异性抗体。Forimtamig 具有 2 + 1 结构，包含两个高亲和力 GPRC5D 结合部分和一个 CD3 结合剂。Forimtamig 还具有 P329G LALA 突变 Fc 结构域，可抑制 Fcγ 受体和 C1q 结合，但仍保留与 Fc 受体的结合。Forimtamig 的同种型对照可以参考人 IgG1 kappa，同种型对照 (HY-P99001)。

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CAS No. : 2649379-96-2

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规格 价格 是否有货 数量
1 mg ￥5000
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Forimtamig 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Forimtamig (RG-6324) is a GPRC5DxCD3 T-cell-engaging bispecific antibody. Forimtamig has a 2 + 1 format, comprising two high-affinity GPRC5D binding moieties and one CD3 binder. Forimtamig further features a P329G LALA mutated Fc domain that inhibits Fcγ receptor and C1q binding, yet retains binding to the neonatal Fc receptor. The isotype control for Forimtamig can refer to Human IgG1 kappa, Isotype Control (HY-P99001)[1].

同型

Human IgG1 kappa
推荐同型对照抗体
反应种属

Human
IC50 & Target

GPRC5D & CD3E
Clinical Trial
基因 ID

55507  [NCBI] & 916  [NCBI]

Accession
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

169.38 kDa

CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • G1-K-L with domain crossover2
Biological Activity
  • Immobilized CD3D-CD3E Heterodimer Protein, Human (HEK293, His, HY-P72726) can bind Forimtamig. The EC50 for this effect is 6.065 ng/mL.
  • Immobilized GPRC5D Protein-VLP, Human (HEK293, His HY-P77958) can bind Forimtamig. The EC50 for this effect is 17.58 ng/mL.
纯度 & 产品资料
参考文献

Forimtamig 相关分类

  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Forimtamig2649379-96-2RG-6234 RO-7425781RG6234RG 6234RO7425781RO 7425781RO-7425781CD3Cluster of differentiation 3GPRC5DxCD3 T-cell-engaging bispecific antibodyInhibitorinhibitorinhibit

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