2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Futuximab

Futuximab  (Synonyms: 伏妥昔单抗)

目录号: HY-P99628

摩尔计算器

Futuximab 是一种嵌合单克隆抗体，靶向 EGFR 上的非重叠表位。Futuximab 具有抗肿瘤活性。

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Futuximab Chemical Structure

Futuximab Chemical Structure

CAS No. : 1310460-85-5

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Futuximab 相关抗体

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Futuximab is a chimeric monoclonal antibody targeting non-overlapping epitopes on EGFR. Futuximab has antineoplastic activity[1].

体外研究
(In Vitro)

Futuximab（20 µg/mL；24-48 小时）诱导 NR6M 细胞中的 EGFR 变体 III (EGFRvIII) 内化并略微降低 EGFRvIII 水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Futuximab 相关抗体:

Western Blot Analysis[1]

Cell Line: NR6M cells
Concentration: 20 µg/mL
Incubation Time: 24 h or 48 h
Result: Slightly reduced EGFRvIII levels in NR6M cells.
体内研究
(In Vivo)

Futuximab（50 mg/kg；i.p.；每周两次；持续 5 周）在表达 EGFRwt 的异种移植模型中显示出抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c nu/nu mice injected with EGFRwt (D08-0308MG) patient-derived glioblastoma xenografts (PDX)[1]
Dosage: 50 mg/kg
Administration: i.p.; twice weekly; for 5 weeks
Result: Inhibited tumor growth in EGFRwt expressing xenograft model.
Clinical Trial
CAS 号
中文名称

伏妥昔单抗
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Futuximab 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Futuximab1310460-85-5伏妥昔单抗EGFREpidermal growth factor receptorErbB-1HER1chimeric monoclonal antibodyantineoplastic activityEGFRvIIIInhibitorinhibitorinhibit

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