1. Metabolic Enzyme/Protease
  2. Drug Metabolite
  3. Gefitinib impurity 5

Gefitinib impurity 5  (Synonyms: 吉非替尼杂质5)

目录号: HY-133779 纯度: 97.43%
COA 产品使用指南

Gefitinib impurity 5 是 Gefitinib 的杂质。Gefitinib 是一种有效的,具有口服活性的选择性EGFR 酪氨酸激酶抑制剂,IC50 为 33 nM。Gefitinib 选择性抑制 EGF 刺激的肿瘤细胞生长 (IC50 为 54 nM),并阻断 EGF 刺激的肿瘤细胞中 EGFR 自磷酸化。Gefitinib 还可诱导细胞自噬 (autophagy)。Gefitinib 具有抗肿瘤活性。

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Gefitinib impurity 5 Chemical Structure

Gefitinib impurity 5 Chemical Structure

CAS No. : 199327-61-2

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Gefitinib impurity 5 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2].

分子量

319.36

Formula

C16H21N3O4

CAS 号
性状

固体

颜色

White to off-white

中文名称

吉非替尼杂质5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 97.43%

参考文献

Gefitinib impurity 5 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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