2. Gene
  3. TANK - TRAF family member associated NFKB activator Gene

TANK - TRAF family member associated NFKB activator Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：TRAF 家族成员相关的 NFKB 激活因子

种属: Homo sapiens

同用名: ITRAF; TRAF2; I-TRAF

基因 ID: 10010 | 基因类型: protein coding

关于 TANK

Cytogenetic location: 2q24.2 Genomic coordinates (GRCh38): 2:161,136,963-161,236,230 (from NCBI)

This gene has 23 transcripts (splice variants) and 187 orthologues. Ubiquitous expression in appendix (RPKM 16.5), lymph node (RPKM 16.3) and 25 other tissues.

功能概要

TRAF (肿瘤坏死因子受体相关因子) 蛋白家族与肿瘤坏死因子受体超家族成员相关并转导信号。由该基因编码的蛋白质存在于细胞质中，可以与 TRAF1、TRAF2 或 TRAF3 结合，从而通过将 TRAF 隔离在细胞质中的潜伏状态来抑制 TRAF 功能。例如，该基因编码的蛋白质可以阻断 TRAF2 与 Epstein-Barr 病毒转化蛋白 LMP1 的结合，并抑制 LMP1 介导的 NF-kappa-B 激活。已经为该基因发现了编码不同同种型的三种选择性剪接的转录物变体。[RefSeq 提供，2010 年 11 月]

The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

TANK 基因产物(3)

mRNA Protein Name
NM_001199135.3 NP_001186064.1 TRAF family member-associated NF-kappa-B activator isoform a
NM_004180.3 NP_004171.2 TRAF family member-associated NF-kappa-B activator isoform a
NM_133484.2 NP_597841.1 TRAF family member-associated NF-kappa-B activator isoform b

TANK 蛋白结构

TBD

TBD: TBD domain (130 - 186)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 425 a.a.
蛋白主名 其他名称

TRAF family member-associated NF-kappa-B activator

TRAF-interacting protein

关联疾病

疾病名称 别名
Nipah Virus Encephalitis

Equine Morbillivirus
Immunodeficiency 33

IMD33

X-Linked Mendelian Susceptibility To Mycobacterial Diseases Due To Ikbkg Deficiency

X-Linked Mendelian Susceptibility To Mycobacterial Diseases Due To Nemo Deficiency

X-Linked Msmd Due To Ikbkg Deficiency

X-Linked Msmd Due To Nemo Deficiency

Invasive Pneumococcal Disease, Recurrent Isolated, 2

Invasive Pneumococcal Disease, Recurrent Isolated, 2, Formerly

Ipd2, Formerly

Nf-Kappa B Essential Modulator Deficiency

Familial X-Linked 1 Atypical Mycobacteriosis

Nemo Deficiency Syndrome

Amcbx1

Familial, X-Linked, Atypical Mycobacteriosis 1

Ipd2

Recurrent Isolated Invasive Pneumococcal Disease 2

X-Linked Disseminated Atypical Mycobacterial Infection Type 1

X-Linked Immunodeficiency 33, Mycobacteriosis

X-Linked Susceptibility To Mycobacterial Disease Type 1

Invasive Pneumococcal Disease, Recurrent Isolated, Type 2

Atypical Mycobacteriosis, Familial, X-Linked 1
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 4

FTDALS4

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-4

Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis, Type 4
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-111941 GSK8612 Inhibitor 99.33% 否
HY-152237 TBK1-IN-1 Inhibitor 99.91% 否
HY-112557 PROTAC TBK1 degrader-2 Inhibitor 98.20% 否
HY-117700 TNKS-IN-2 Inhibitor / 否
HY-RS14197 TANK Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus TANK RGD RGD:628859
Felis catus TANK VGNC VGNC:65952
Mus musculus TANK MGD MGI:107676
Bos taurus TANK VGNC VGNC:35594
Macaca mulatta TANK VGNC VGNC:78097
Canis familiaris TANK VGNC VGNC:47101
Others TANK NCBI
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