2. Gene
  3. CDH6 - cadherin 6 Gene

CDH6 - cadherin 6 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：钙粘素 6

种属: Homo sapiens

同用名: CAD6; KCAD

基因 ID: 1004 | 基因类型: protein coding

关于 CDH6

Cytogenetic location: 5p13.3 Genomic coordinates (GRCh38): 5:31,193,686-31,329,146 (from NCBI)

This gene has 5 transcripts (splice variants), 263 orthologues and 33 paralogues. Broad expression in kidney (RPKM 6.1), gall bladder (RPKM 4.1) and 17 other tissues.

功能概要

该基因编码钙粘蛋白超家族的一个成员。钙粘蛋白是一种膜糖蛋白，可介导嗜同性细胞间粘附，并在细胞分化和形态发生中发挥关键作用。编码的蛋白质是一种 II 型钙粘蛋白，可能在肾脏发育以及子宫内膜和胎盘形成中发挥作用。该基因表达降低可能与肿瘤生长和转移有关。[RefSeq 提供，2011 年 5 月]

This gene encodes a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. The encoded protein is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis. [provided by RefSeq, May 2011]

CDH6 基因产物(2)

mRNA Protein Name
NM_001362435.2 NP_001349364.1 cadherin-6 isoform 2 preproprotein
NM_004932.4 NP_004923.1 cadherin-6 isoform 1 preproprotein

CDH6 蛋白结构

Cadherin

Cadherin: Cadherin domain (74 - 149)

Cadherin

Cadherin: Cadherin domain (164 - 258)

Cadherin

Cadherin: Cadherin domain (273 - 357)

Cadherin

Cadherin: Cadherin domain (390 - 479)

Cadherin

Cadherin: Cadherin domain (492 - 589)

Cadherin_C

Cadherin_C: Cadherin cytoplasmic region (638 - 783)

  • 0
  • 200
  • 400
  • 600
  • 790 a.a.
蛋白主名 其他名称

cadherin-6

cadherin 6, type 2, K-cadherin (fetal kidney)

重组 CDH6 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7702 Cadherin-6/KCAD Protein, Human (HEK293, Fc) P55285 (T19-A615) ≥95%
HY-P7703 Cadherin-6/KCAD Protein, Human (594a.a, HEK293, His) P55285 (T22-A615) ≥95%
HY-P77036 Cadherin-6/KCAD Protein, Human (615a.a, HEK293, His) P55285 (M1-A615) ≥95%

关联疾病

疾病名称 别名
Craniofacial-Deafness-Hand Syndrome

CDHS

Craniofacial Deafness Hand Syndrome

Sommer-Young-Wee-Frye Syndrome

Features Of Flat Facial Profile, Hypertelorism, Hypoplastic Nose With Slitlike Nares, And A Sensorineural Hearing Loss

Craniofacial-Hearing Loss-Hand Syndrome
Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma

RCC

Nonpapillary Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma

Hypernephroma

Adenocarcinoma Of Kidney

Renal Carcinoma, Chromophobe, Somatic

Clear Cell Carcinoma Of Kidney

Clear-Cell Metastatic Renal Cell Carcinoma

Clear Cell Renal Carcinoma

Renal Cell Carcinoma, Somatic

Conventional Renal Cell Carcinoma

Conventional Renal Cell Carcinoma

Renal Clear Cell Carcinoma

Ccrcc

Hereditary Clear Cell Renal Cell Carcinoma

Carcinoma, Renal Cell

Renal Cell Carcinoma, Clear Cell, Somatic

Renal Cell Carcinoma, Clear Cell

Clear Cell Kidney Carcinoma

Clear Cell Rcc

Cystic-Multilocular Variant

Clear Cell Renal Cell Adenocarcinoma

Hereditary Clear Cell Renal Cell Adenocarcinoma

Common Renal Cell Carcinoma

Crcc

Renal Cell Carcinoma Non-Papillary

Carcinoma Renal Cell

Renal Cell Cancer

Carcinoma, Renal Cell, Nonpapillary
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02339 CDH6 Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta CDH6 VGNC VGNC:70974
Mus musculus CDH6 MGD MGI:107435
Canis familiaris CDH6 VGNC VGNC:50872
Bos taurus CDH6 VGNC VGNC:27105
Rattus norvegicus CDH6 RGD RGD:2322
Felis catus CDH6 VGNC VGNC:60685
Macaca fascicularis CDH6 NCBI
Others CDH6 NCBI
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