CLPX - caseinolytic mitochondrial matrix peptidase chaperone subunit X Gene

中文名称：酪蛋白分解线粒体基质肽酶伴侣亚基 X

种属: Homo sapiens

同用名: EPP2

基因 ID: 10845 | 基因类型: protein coding

关于 CLPX

Cytogenetic location: 15q22.31 Genomic coordinates (GRCh38): 15:65,148,219-65,185,342 (from NCBI)

This gene has 6 transcripts (splice variants), 239 orthologues and is associated with 1 phenotype. Ubiquitous expression in liver (RPKM 13.6), testis (RPKM 11.0) and 25 other tissues.

功能概要

由该基因编码的蛋白质是在线粒体中发现的蛋白酶的一部分。这种蛋白酶是 ATP 依赖性的，靶向特定蛋白质进行降解。该蛋白酶由 ClpP 催化亚基的两个七聚体环组成，夹在由该基因编码的伴侣亚基的两个六聚体环之间。目标蛋白被该蛋白解开，然后传递给 ClpP 亚基进行降解。已发现该基因的两种转录变体，一种是蛋白质编码，另一种是非蛋白质编码。[RefSeq 提供，2015 年 11 月]

The protein encoded by this gene is part of a protease found in mitochondria. This protease is ATP-dependent and targets specific proteins for degradation. The protease consists of two heptameric rings of the ClpP catalytic subunit sandwiched between two hexameric rings of the chaperone subunit encoded by this gene. Targeted proteins are unwound by this protein and then passed on to the ClpP subunit for degradation. Two transcript variants, one protein-coding and the Other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2015]

CLPX 基因产物(1)

mRNA	Protein	Name
NM_006660.5	NP_006651.2	ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ATP hydrolysis activity	IDA IDA: 通过直接分析推断	22710082	GOA
contributes to ATP-dependent peptidase activity	IDA IDA: 通过直接分析推断	16115876	GOA
enables peptidase activator activity	IDA IDA: 通过直接分析推断	11923310	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11923310	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in ATP metabolic process	IDA IDA: 通过直接分析推断	22710082	GOA
involved in proteolysis	IDA IDA: 通过直接分析推断	15522782	GOA
involved in proteolysis involved in protein catabolic process	IDA IDA: 通过直接分析推断	16115876	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of endopeptidase Clp complex	IDA IDA: 通过直接分析推断	11923310	GOA
part of endopeptidase Clp complex	IPI IPI: 通过物理相互作用推断	15522782	GOA
part of mitochondrial endopeptidase Clp complex	IDA IDA: 通过直接分析推断	16115876	GOA
located in mitochondrial matrix	IDA IDA: 通过直接分析推断	10525407	GOA
located in mitochondrial nucleoid	IDA IDA: 通过直接分析推断	18063578	GOA
located in mitochondrion	IDA IDA: 通过直接分析推断	11003706	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CLPX 蛋白结构

AAA_2

ClpB_D2-small

0
100
200
300
400
500
633 a.a.

蛋白主名

其他名称

ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial

ClpX caseinolytic peptidase X homolog

CLPX 抗体

目录号	产品名	应用	反应物种
HY-P83069	CLPX Antibody (YA2814)	WB, ICC/IF	Human, Mouse, Rat, Hamster

关联疾病

疾病名称

别名

Protoporphyria, Erythropoietic, 2

EPP2

Tick-Borne Relapsing Fever

Relapsing Fever, Tick-Borne	Relapsing Fever Due To Any Borrelia Species Other Than Borrelia Recurrentis
African Tick-Borne Fever

Porphyria

Hematoporphyria	Porphyrias
Disorder Of Porphyrin And Hem Metabolism	Disorder Of Porphyrin Metabolism
Porphyrinopathy	Porphyrin Disorder
Disorder Of Porphyrin And Heme Metabolism	Disorders Of Porphyrin Metabolism

Acrodermatitis Chronica Atrophicans

Acrodermatitis Atrophicans Chronica	Herxheimer Disease
Primary Diffuse Atrophy

Spinocerebellar Ataxia 28

Spinocerebellar Ataxia Type 28	SCA28
Ataxia, Spinocerebellar, Type 28

Relapsing Fever

Febris Recurrens	Novy Febris Recurrens
Novy Relapsing Fever

Codas Syndrome

Cerebral, Ocular, Dental, Auricular, And Skeletal Anomalies Syndrome	Cerebral, Ocular, Dental, Auricular, And Skeletal Syndrome
Cerebro-Oculo-Dento-Auriculo-Skeletal Syndrome	Cerebrooculodentoauriculoskeletal Syndrome
CODASS	Cerebral, Ocular, Dental, Auricular, Skeletal Syndrome

Protoporphyria, Erythropoietic, 1

Erythropoietic Protoporphyria	Epp
Ferrochelatase Deficiency	Protoporphyria, Erythropoietic
Erythrohepatic Protoporphyria	Heme Synthetase Deficiency
Autosomal Erythropoietic Protoporphyria	EPP1
Protoporphyria	Protoporphyria Erythropoietic

Spastic Ataxia 5

Perrault Syndrome

Gonadal Dysgenesis, Xx Type, With Deafness	Ovarian Dysgenesis With Sensorineural Deafness
Gonadal Dysgenesis, Xx Type	Gonadal Dysgenesis With Auditory Dysfunction, Autosomal Recessive Inheritance
Gonadal Dysgenesis With Sensorineural Deafness, Autosomal Recessive Inheritance	Xx Gonodal Dysgenesis-Deafness Syndrome
Xx Gonodal Dysgenesis-Hearing Loss Syndrome	Gonadal Dysgenesis Xx Type Deafness

Cutaneous Porphyria

Porphyria, Erythropoietic

Erythropoietic Porphyria

Acute Porphyria

Porphyrias, Hepatic	Hepatic Porphyria
Porphyria Hepatic	Acute Intermittent Porphyria

Porphyria Cutanea Tarda

Hepatoerythropoietic Porphyria	HEP
Uroporphyrinogen Decarboxylase Deficiency	Pct
Pct, Type Ii	Porphyria, Hepatocutaneous Type
Urod Deficiency	Porphyria, Hepatoerythropoietic
Porphyria Cutanea Tarda, Susceptibility To	Familial Porphyria Cutanea Tarda
Porphyria Cutanea Tarda, Type Ii	Pct, 'Familial' Type
Porphyria, Hepatic	FPCT
Pct Type Ii	Porphyria Cutanea Tarda Type Ii
Porphyria Hepatocutaneous Type	Heterozygous Uroporphyrinogen Decarboxylase Deficiency
Urod - [Uroporphyrinogen Decarboxylase] Deficiency	Pct - [Porphyria Cutanea Tarda]

Granulomatous Disease, Chronic, Autosomal Recessive, 2

Chronic Granulomatous Disease Due To Deficiency Of Ncf-2	CGD2
Ncf2 Deficiency	P67-Phox Deficiency
Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type Ii	Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 2
Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type Ii	Cgd, Autosomal Recessive Cytochrome B-Positive, Type Ii
Granulomatous Disease, Chronic, Due To Ncf2 Deficiency	Neutrophil Cytosol Factor 2 Deficiency
Chronic Granulomatous Disease 2, Autosomal Recessive	Autosomal Recessive Chronic Granulomatous Disease 2
Cdg2	Deficiency Of Ncf2
Deficiency Of P67-Phox	Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type Ii
Deficiency Of Neutrophil Cytosol Factor 2	Avellino Corneal Dystrophy

Coproporphyria, Hereditary

Hereditary Coproporphyria	Coproporphyria
Coproporphyrinogen Oxidase Deficiency	HCP
Cpo Deficiency	Cpox Deficiency
Cpx Deficiency	Hereditary Coproporphyria Porphyria
Cpro Deficiency	Coproporphyria Hereditary
Porphyria Hepatica Ii	Porphyria Hepatica Coproporphyria
Porphyria, Hereditary Coproporphyria	Harderoporphyria

Variegate Porphyria

Porphyria Variegata	Protoporphyrinogen Oxidase Deficiency
VP	Ppox Deficiency
Porphyria, South African Type	Porphyria Variegata, Susceptibility To
Protocoproporphyria	Porphyria Variegate
Porphyria South African Type	Pv
Porphyria, Variegate	Vp - [Variegate Porphyria]

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia	Hereditary Spastic Paraparesis
Strumpell-Lorrain Disease	Familial Spastic Paraparesis
Hsp	Spg
Strümpell-Lorrain Disease	Spastic Paraplegia, Hereditary
French Settlement Disease	Strumpell-Lorrain Syndrome
Fsp	Spastic Paraplegia, Familial
Spastic Paraplegia Hereditary	Spastic Paraplegia 3, Autosomal Dominant
Spastic Paraparesis	Hereditary Spastic Paralysis
Familial Spastic Paralysis	Hereditary Spastic Ataxia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02835	CLPX Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS22125	Clpx Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS28647	Clpx Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	CLPX	VGNC	VGNC:84326
Bos taurus	CLPX	VGNC	VGNC:27462
Mus musculus	CLPX	MGD	MGI:1346017
Rattus norvegicus	CLPX	RGD	RGD:1304883
Felis catus	CLPX	VGNC	VGNC:60976
Canis familiaris	CLPX	VGNC	VGNC:39359

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CLPX - caseinolytic mitochondrial matrix peptidase chaperone subunit X Gene

关于 CLPX

功能概要

CLPX 基因产物(1)

CLPX 蛋白结构

CLPX 抗体

关联疾病

直系同源

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CLPX - caseinolytic mitochondrial matrix peptidase chaperone subunit X Gene

关于 CLPX

功能概要

CLPX 基因产物(1)

CLPX 蛋白结构

CLPX 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z