ME3 - malic enzyme 3 Gene

中文名称：苹果酸酶 3

种属: Homo sapiens

同用名: NADP-ME

关于 ME3

功能概要

苹果酸酶使用 NAD+ 或 NADP+ 作为辅因子催化苹果酸氧化脱羧为丙酮酸。哺乳动物组织包含 3 种不同的苹果酸酶亚型：细胞溶质 NADP (+) 依赖型、线粒体 NADP (+) 依赖型和线粒体 NAD (+) 依赖型。该基因编码线粒体 NADP (+) 依赖性异构体。已发现该基因的多个选择性剪接转录变体，但尚未确定某些变体的生物学有效性。[RefSeq 提供，2008 年 7 月]

Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent isoform. This gene encodes a mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]