2. Epigenetics
  3. Histone Demethylase
  4. GSK-J1 sodium

GSK-J1 sodium 是 H3K27me3/me2-demethylases JMJD3/KDM6B 和 UTX/KDM6A 的抑制剂，对 KDM6B 的 IC50 值为 60 nM。

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GSK-J1 sodium Chemical Structure

GSK-J1 sodium Chemical Structure

CAS No. : 1797832-71-3

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GSK-J1 sodium 的其他形式现货产品:

Customer Review

Other Forms of GSK-J1 sodium:

GSK-J1 sodium 相关抗体

Top Publications Citing Use of Products

    GSK-J1 sodium purchased from MCE. Usage Cited in: Front Mol Neurosci. 2017 Mar 13;10:51.  [Abstract]

    GSK-J1 impaired zebrafish hair cell regeneration. 5 dpf larvae are treated with 400 μM Neomycin for 1 h followed by GSK-J1 exposure for 24 in the presence of BrdU. GSK-J1 significantly reduces the numbers of myosinVI-positive (green) hair cells and BrdU-positive (red) replicating cells.

    查看 Histone Demethylase 亚型特异性产品:

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    KDM1/LSD1 KDM2 KDM3 KDM4 KDM5 KDM6

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    GSK-J1 sodium is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, with IC50 value of 60 nM towards KDM6B[1][2][3].

    IC50 & Target

    IC50: 60 nM (KDM6B)[2]
    分子量

    411.43

    Formula

    C22H22N5NaO2
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    GSK-J1 sodium 相关分类

    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

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    The dilution calculator equation

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    GSK-J11797832-71-3Histone DemethylaseInhibitorinhibitorinhibit

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