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UNC4976 

目录号: HY-126327
产品使用指南

UNC4976 是一种显着改善细胞效力的 CBX7 化学探针。UNC4976 作为一种 CBX7 染色质结构域与核酸结合的正变构调节剂 (PAM),对染色质上的 PRC1 占据和细胞内 Polycomb 靶基因的基因表达具有快速影响。UNC4976 拮抗 H3K27me3 特异性募集 CBX7 至靶基因,同时增加与 DNA 和 RNA 的非特异性结合,增强了三种正交细胞测定中的功效。

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UNC4976 Chemical Structure

UNC4976 Chemical Structure

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Description

UNC4976 is a significantly improved cellularly efficacious chemical probe of CBX7. UNC4976 acts as a positive allosteric modulator (PAM) of CBX7 chromodomain binding to nucleic acids with rapid impacts on both PRC1 occupancy on chromatin and gene expression at Polycomb target genes within cells. UNC4976 results enhanced efficacy across three orthogonal cellular assays by simultaneously antagonizing H3K27me3-specific recruitment of CBX7 to target genes while increasing non-specific binding to DNA and RNA[1].

Molecular Weight

847.09

Formula

C₄₇H₇₀N₆O₈

SMILES

COC([C@H](CO)NC([C@H](CCCCN(C)C1C2CCC(C2)C1)NC([C@H](CC(C)C)NC([C@H](C)NC([C@H](CC3=CC=CC=C3)NC(C4=CC=C(C(C)(C)C)C=C4)=O)=O)=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
UNC4976
目录号:
HY-126327
需求量:

UNC4976

Cat. No.: HY-126327