2. Epigenetics
  3. Histone Methyltransferase
  4. EZH2-IN-1

EZH2-IN-1 (compound 3) 是一种选择性且 SAM 竞争性的 EZH2 和 EZH1 抑制剂，对 EZH2wt、EZH2 Y641N 突变体和 EZH1 的 IC50 值分别为 32 nM、197 nM 和 213 nM。EZH2-IN-1 降低了 H3K27me3 和 H3K27me2 的总体水平。EZH2-IN-1具有用于弥漫性大B细胞淋巴瘤研究的潜力。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

EZH2-IN-1

EZH2-IN-1 Chemical Structure

CAS No. : 1377997-28-8

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

EZH2-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Histone Methyltransferase 亚型特异性产品:

查看所有亚型
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EZH2-IN-1 (compound 3) is a selective and SAM-competitive EZH2 and EZH1 inhibitor with an IC50s of 32 nM, 197 nM and 213 nM for EZH2wt, EZH2 Y641N mutant and EZH1, respectively. EZH2-IN-1 reduces bulk H3K27me3 and H3K27me2 levels. EZH2-IN-1 has the potential for diffuse large B cell lymphoma research[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HeLa EC50
7 μM
Compound: 23
Inhibition of EZH2 in human HeLa cells assessed as reduction of H3K27me3 and H3K27me2 level after 96 hrs by ELISA method
Inhibition of EZH2 in human HeLa cells assessed as reduction of H3K27me3 and H3K27me2 level after 96 hrs by ELISA method
[PMID: 25406853]
KARPAS-422 GI50
13.2 μM
Compound: 44
Growth inhibition of human KARPAS422 cells after 14 days by Cell-Titer luminescence assay
Growth inhibition of human KARPAS422 cells after 14 days by Cell-Titer luminescence assay
[PMID: 24900844]
KARPAS-422 GI50
23 μM
Compound: 44
Growth inhibition of human KARPAS422 cells after 10 days by Cell-Titer luminescence assay
Growth inhibition of human KARPAS422 cells after 10 days by Cell-Titer luminescence assay
[PMID: 24900844]
KARPAS-422 GI50
24.8 μM
Compound: 44
Growth inhibition of human KARPAS422 cells after 7 days by Cell-Titer luminescence assay
Growth inhibition of human KARPAS422 cells after 7 days by Cell-Titer luminescence assay
[PMID: 24900844]
KARPAS-422 GI50
70 μM
Compound: 44
Growth inhibition of human KARPAS422 cells after 4 days by Cell-Titer luminescence assay
Growth inhibition of human KARPAS422 cells after 4 days by Cell-Titer luminescence assay
[PMID: 24900844]
KARPAS-422 GI50
9.1 μM
Compound: 44
Growth inhibition of human KARPAS422 cells after 17 days by Cell-Titer luminescence assay
Growth inhibition of human KARPAS422 cells after 17 days by Cell-Titer luminescence assay
[PMID: 24900844]
分子量

490.00

Formula

C27H28ClN5O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EZH2-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EZH2-IN-11377997-28-8Histone MethyltransferaseSAMEZH2EZH1EZH2wtEZH2 Y641N mutantH3K27me3H3K27me2diffuse large B cell lymphomaInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
EZH2-IN-1
目录号：
HY-122595
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z