2. Gene
  3. LMAN2 - lectin, mannose binding 2 Gene

LMAN2 - lectin, mannose binding 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：凝集素，甘露糖结合 2

种属: Homo sapiens

同用名: GP36B; VIP36; C5orf8

基因 ID: 10960 | 基因类型: protein coding

关于 LMAN2

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:177,331,567-177,351,668 (from NCBI)

This gene has 11 transcripts (splice variants), 208 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 56.0), testis (RPKM 45.6) and 25 other tissues.

功能概要

该基因编码 I 型跨膜凝集素，在内质网、高尔基体和质膜之间穿梭。编码的蛋白质结合高甘露糖型糖蛋白，可能有助于它们的分类、运输和质量控制。[RefSeq 提供，2008 年 10 月]

This gene encodes a type I transmembrane lectin that shuttles between the endoplasmic reticulum, the Golgi apparatus and the plasma membrane. The encoded protein binds high mannose type glycoproteins and may facilitate their sorting, trafficking and quality control. [provided by RefSeq, Oct 2008]

LMAN2 基因产物(1)

mRNA Protein Name
NM_006816.3 NP_006807.1 vesicular integral-membrane protein VIP36 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables D-mannose binding IMP
IMP: 通过突变表型推断
20477988 GOA
enables carbohydrate binding IDA
IDA: 通过直接分析推断
23701871 GOA
enables heat shock protein binding IPI
IPI: 通过物理相互作用推断
20477988 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20477988 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of phagocytosis IMP
IMP: 通过突变表型推断
22016386 GOA
involved in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IMP
IMP: 通过突变表型推断
20477988 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
20477988 GOA
located in cell surface IDA
IDA: 通过直接分析推断
22016386 GOA
located in endoplasmic reticulum-Golgi intermediate compartment IDA
IDA: 通过直接分析推断
15308636 GOA
located in extracellular space IDA
IDA: 通过直接分析推断
22016386 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
22016386 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LMAN2 蛋白结构

Lectin_leg-like

Lectin_leg-like: Legume-like lectin family (53 - 277)

  • 0
  • 100
  • 200
  • 300
  • 356 a.a.
蛋白主名 其他名称

vesicular integral-membrane protein VIP36

epididymis secretory sperm binding protein

重组 LMAN2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71151 LMAN2 Protein, Human (HEK293, His) Q12907 (D45-R322) ≥95%

关联疾病

疾病名称 别名
Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07704 LMAN2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS07705 LMAN2L Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19214 Lman2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20562 Lman2l Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25703 Lman2 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27071 Lman2l Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus LMAN2 VGNC VGNC:63246
Canis familiaris LMAN2 VGNC VGNC:42708
Mus musculus LMAN2 MGD MGI:1914140
Rattus norvegicus LMAN2 RGD RGD:1308965
Macaca mulatta LMAN2 VGNC VGNC:74302
Bos taurus LMAN2 VGNC VGNC:30920
Others LMAN2 NCBI
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