DUSP10 - dual specificity phosphatase 10 Gene

中文名称：双特异性磷酸酶 10

种属: Homo sapiens

同用名: MKP5; MKP-5

关于 DUSP10

功能概要

双特异性蛋白磷酸酶通过使磷酸丝氨酸/苏氨酸和磷酸酪氨酸残基去磷酸化来灭活它们的靶激酶。它们负向调节与细胞增殖和分化相关的 MAP 激酶超家族成员。该双特异性磷酸酶家族的不同成员对 MAP 激酶表现出不同的底物特异性、不同的组织分布和亚细胞定位以及不同的细胞外刺激表达诱导模式。该基因产物结合并使 p38 和 SAPK/JNK 失活。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 4 月]

Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]