2. Gene
  3. Abl2 - v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene) Gene

Abl2 - v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene) Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Arg; Abll

基因 ID: 11352 | 基因类型: protein coding

关于 Abl2

功能概要

Enables magnesium ion binding activity; manganese ion binding activity; and protein tyrosine kinase activity. Involved in actin Cytoskeleton organization; peptidyl-tyrosine phosphorylation; and synapse maturation. Acts upstream of or within several processes, including nervous system development; regulation of signal transduction; and transmembrane receptor protein tyrosine kinase signaling pathway. Located in several cellular components, including dendritic spine; lamellipodium; and phagocytic cup. Is active in glutamatergic synapse. Is expressed in several structures, including brain; diaphragm; hindlimb long bone; liver; and seminiferous cord. Orthologous to human ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Abl2 基因产物(2)

mRNA Protein Name
NM_001136104.1 NP_001129576.1 tyrosine-protein kinase ABL2 isoform a
NM_009595.3 NP_033725.2 tyrosine-protein kinase ABL2 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables magnesium ion binding IDA
IDA: 通过直接分析推断
12748290 MGI
enables manganese ion binding IDA
IDA: 通过直接分析推断
12748290 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
19414610 MGI
enables protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
12748290 MGI
enables protein tyrosine kinase activity IGI
IGI: 通过遗传相互作用推断
18827006 MGI
enables protein tyrosine kinase activity IMP
IMP: 通过突变表型推断
15084284 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within Bergmann glial cell differentiation IGI
IGI: 通过遗传相互作用推断
20980600 MGI
acts upstream of or within DN4 thymocyte differentiation IGI
IGI: 通过遗传相互作用推断
18025176 MGI
acts upstream of Rho protein signal transduction IGI
IGI: 通过遗传相互作用推断
23595732 MGI
involved in actin cytoskeleton organization IDA
IDA: 通过直接分析推断
11752434 MGI
acts upstream of or within actin cytoskeleton organization IGI
IGI: 通过遗传相互作用推断
9883720 MGI
acts upstream of or within actin filament bundle assembly IDA
IDA: 通过直接分析推断
11752434 MGI
acts upstream of or within actin filament organization IDA
IDA: 通过直接分析推断
11752434 MGI
acts upstream of or within adult walking behavior IMP
IMP: 通过突变表型推断
9883720 MGI
acts upstream of or within aggressive behavior IMP
IMP: 通过突变表型推断
9883720 MGI
acts upstream of or within alpha-beta T cell differentiation IGI
IGI: 通过遗传相互作用推断
18025176 MGI
acts upstream of or within auditory behavior IMP
IMP: 通过突变表型推断
9883720 MGI
acts upstream of canonical NF-kappaB signal transduction IGI
IGI: 通过遗传相互作用推断
18025176 MGI
acts upstream of cell-cell adhesion IGI
IGI: 通过遗传相互作用推断
24367707 MGI
acts upstream of or within cerebellum morphogenesis IGI
IGI: 通过遗传相互作用推断
20980600 MGI
acts upstream of or within circulatory system development IGI
IGI: 通过遗传相互作用推断
9883720 MGI
acts upstream of or within dendrite morphogenesis IGI
IGI: 通过遗传相互作用推断
22357865 MGI
acts upstream of or within dendrite morphogenesis IMP
IMP: 通过突变表型推断
23365224 MGI
acts upstream of or within dendritic spine maintenance IGI
IGI: 通过遗传相互作用推断
23365224 MGI
acts upstream of or within dendritic spine maintenance IMP
IMP: 通过突变表型推断
23365224 MGI
acts upstream of or within epidermal growth factor receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
18827006 MGI
acts upstream of or within establishment of localization in cell IGI
IGI: 通过遗传相互作用推断
23100514 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: 通过突变表型推断
22665498 MGI
acts upstream of or within exploration behavior IGI
IGI: 通过遗传相互作用推断
23595732 MGI
acts upstream of or within learning IMP
IMP: 通过突变表型推断
19805386 MGI
acts upstream of or within multicellular organism growth IMP
IMP: 通过突变表型推断
9883720 MGI
acts upstream of or within negative regulation of Rho protein signal transduction IGI
IGI: 通过遗传相互作用推断
15084284 MGI
acts upstream of or within negative regulation of cell-cell adhesion IGI
IGI: 通过遗传相互作用推断
24367707 MGI
acts upstream of or within negative regulation of endothelial cell apoptotic process IGI
IGI: 通过遗传相互作用推断
23840065 MGI
acts upstream of or within neural tube closure IGI
IGI: 通过遗传相互作用推断
9883720 MGI
acts upstream of or within neuroepithelial cell differentiation IGI
IGI: 通过遗传相互作用推断
9883720 MGI
acts upstream of or within neuromuscular process controlling balance IGI
IGI: 通过遗传相互作用推断
20980600 MGI
acts upstream of or within neuromuscular process controlling balance IMP
IMP: 通过突变表型推断
9883720 MGI
acts upstream of or within neuron differentiation IGI
IGI: 通过遗传相互作用推断
9883720 MGI
acts upstream of or within neuron remodeling IMP
IMP: 通过突变表型推断
19805386 MGI
involved in peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
12748290 MGI
acts upstream of or within phagocytosis IGI
IGI: 通过遗传相互作用推断
23100514 MGI
acts upstream of or within phagocytosis IMP
IMP: 通过突变表型推断
22665498 MGI
acts upstream of or within platelet-derived growth factor receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
18827006 MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade IGI
IGI: 通过遗传相互作用推断
18827006 MGI
involved in positive regulation of T cell migration IMP
IMP: 通过突变表型推断
22810897 MGI
acts upstream of or within positive regulation of Wnt signaling pathway, planar cell polarity pathway IGI
IGI: 通过遗传相互作用推断
20837657 MGI
acts upstream of or within positive regulation of canonical NF-kappaB signal transduction IGI
IGI: 通过遗传相互作用推断
18025176 MGI
involved in positive regulation of establishment of T cell polarity IMP
IMP: 通过突变表型推断
22810897 MGI
acts upstream of or within positive regulation of interleukin-2 production IGI
IGI: 通过遗传相互作用推断
18025176 MGI
acts upstream of or within positive regulation of neuron projection development IGI
IGI: 通过遗传相互作用推断
15084284 MGI
acts upstream of or within positive regulation of protein binding IMP
IMP: 通过突变表型推断
15084284 MGI
acts upstream of or within positive regulation of type II interferon production IGI
IGI: 通过遗传相互作用推断
18025176 MGI
acts upstream of or within post-embryonic development IGI
IGI: 通过遗传相互作用推断
9883720 MGI
acts upstream of or within protein localization IMP
IMP: 通过突变表型推断
23365224 MGI
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
12748290 MGI
acts upstream of or within regulation of extracellular matrix organization IGI
IGI: 通过遗传相互作用推断
20980600 MGI
acts upstream of or within reproductive process IMP
IMP: 通过突变表型推断
9883720 MGI
acts upstream of or within substrate-dependent cell migration, cell extension IGI
IGI: 通过遗传相互作用推断
19414610 MGI
involved in synapse maturation IDA
IDA: 通过直接分析推断
27335408 MGI
involved in synapse maturation IMP
IMP: 通过突变表型推断
27335408 MGI
acts upstream of or within visual learning IGI
IGI: 通过遗传相互作用推断
22357865 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in actin cytoskeleton IDA
IDA: 通过直接分析推断
11752434 MGI
located in dendritic spine IDA
IDA: 通过直接分析推断
23365224 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
23365224 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
23365224 MGI
located in lamellipodium IDA
IDA: 通过直接分析推断
19414610 MGI
located in phagocytic cup IDA
IDA: 通过直接分析推断
23100514 MGI
is active in postsynapse IDA
IDA: 通过直接分析推断
23365224 MGI
is active in postsynapse IMP
IMP: 通过突变表型推断
23365224 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

tyrosine-protein kinase ABL2

Abelson tyrosine-protein kinase 2

Abelson-related gene protein

abelson murine leukemia viral oncogene homolog 2

tyrosine kinase ARG

tyrosine-protein kinase ARG

v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-148794 Risvodetinib Inhibitor 99.21% Phase 2
Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-148063 DB0614 98.80% 否
HY-148061 DB1113 99.22% 否
HY-RS00105 ABL2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18744 Abl2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25231 Abl2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Abl2 NCBI NCBI:27
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