2. Gene
  3. Acadl - acyl-Coenzyme A dehydrogenase, long-chain Gene

Acadl - acyl-Coenzyme A dehydrogenase, long-chain Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: LCAD

基因 ID: 11363 | 基因类型: protein coding

关于 Acadl

功能概要

This gene encodes a homotetrameric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum length between C12- and C16-acylCoA. In mice, deficiency of this gene can cause sudden death, cardiomyopathy as well as fasting and cold intolerance. [provided by RefSeq, Nov 2012]

Acadl 基因产物(1)

mRNA Protein Name
NM_007381.4 NP_031407.2 long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables long-chain fatty acyl-CoA dehydrogenase activity IMP
IMP: 通过突变表型推断
9861014 MGI
enables palmitoyl-CoA oxidase activity IMP
IMP: 通过突变表型推断
9861014 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in carnitine catabolic process IMP
IMP: 通过突变表型推断
9861014 MGI
involved in carnitine metabolic process, CoA-linked IMP
IMP: 通过突变表型推断
9861014 MGI
involved in cellular lipid catabolic process IMP
IMP: 通过突变表型推断
9861014 MGI
involved in fatty acid beta-oxidation using acyl-CoA dehydrogenase IMP
IMP: 通过突变表型推断
15639194 MGI
acts upstream of or within fatty acid catabolic process IMP
IMP: 通过突变表型推断
21151927 MGI
involved in negative regulation of fatty acid biosynthetic process IMP
IMP: 通过突变表型推断
15639194 MGI
involved in negative regulation of fatty acid oxidation IMP
IMP: 通过突变表型推断
15639194 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: 通过突变表型推断
9802886 MGI
involved in regulation of cholesterol metabolic process IMP
IMP: 通过突变表型推断
15639194 MGI
acts upstream of or within response to cold IMP
IMP: 通过突变表型推断
21151927 MGI
involved in temperature homeostasis IMP
IMP: 通过突变表型推断
15639194 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrion IDA
IDA: 通过直接分析推断
26767982 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

long-chain specific acyl-CoA dehydrogenase, mitochondrial

acetyl-Coenzyme A dehydrogenase, long-chain

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00127 ACADL Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19401 Acadl Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25893 Acadl Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Acadl NCBI NCBI:33
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