2. Gene
  3. Inpp5e - inositol polyphosphate-5-phosphatase E Gene

Inpp5e - inositol polyphosphate-5-phosphatase E Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 114089 | 基因类型: protein coding

关于 Inpp5e

功能概要

Enables inositol-polyphosphate 5-phosphatase activity; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; and phosphatidylinositol-4,5-bisphosphate Phosphatase activity. Involved in negative regulation of phosphatidylinositol 3-kinase signaling and negative regulation of translation. Located in cytoplasm; plasma membrane; and ruffle. Biomarker of obesity. Human ortholog(s) of this gene implicated in Joubert syndrome and Joubert syndrome 1. Orthologous to human INPP5E (inositol polyphosphate-5-phosphatase E). [provided by Alliance of Genome Resources, Apr 2022]

Inpp5e 基因产物(1)

mRNA Protein Name
NM_053632.1 NP_446084.1 phosphatidylinositol polyphosphate 5-phosphatase type IV
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables inositol-polyphosphate 5-phosphatase activity IDA
IDA: 通过直接分析推断
10405344 RGD
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IDA
IDA: 通过直接分析推断
21436142 RGD
enables phosphatidylinositol-4,5-bisphosphate phosphatase activity IDA
IDA: 通过直接分析推断
21436142 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: 通过直接分析推断
21436142 RGD
involved in negative regulation of translation IDA
IDA: 通过直接分析推断
21436142 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in ruffle IDA
IDA: 通过直接分析推断
10405344 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

phosphatidylinositol polyphosphate 5-phosphatase type IV

5-phosphatase that induces arborization

72 kDa inositol polyphosphate 5-phosphatase

inositol polyphosphate 5-phosphatase

pharbin

phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase

phosphatidylinositol-4,5-bisphosphate 5-phosphatase

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06830 INPP5E Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS10770 PMPCA Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21143 Inpp5e Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27660 Inpp5e Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Inpp5e NCBI NCBI:56623
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