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  3. Acvr1 - activin A receptor, type 1 Gene

Acvr1 - activin A receptor, type 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：激活素 A 受体，1 型

种属: Mus musculus

同用名: ALK2; Acvr; Alk8; SKR1; Alk-2; Tsk7L; ActR-I; ActRIA; Acvr1a; Acvrlk2; D330013D15Rik

基因 ID: 11477 | 基因类型: protein coding

关于 Acvr1

Chromosome 2: 58,278,656-58,457,169 reverse strand.GRCm39:CM000995.3

This gene has 6 transcripts (splice variants), 174 orthologues, 11 paralogues and is associated with 43 phenotypes. Ubiquitous expression in bladder adult (RPKM 6.5), limb E14.5 (RPKM 6.5) and 28 other tissues.

功能概要

激活激活素结合活动；转化生长因子β结合活性；和跨膜受体蛋白丝氨酸/苏氨酸激酶活性。参与心脏发育；参与心内膜垫形成的上皮间充质转化的正调节；氮化合物代谢过程的正向调控。作用于多个过程的上游或内部，包括脊索动物胚胎发育；循环系统发育；和原肠胚形成。位于细胞顶端。是质膜的组成部分。以多种结构表达，包括消化系统；脑;肢;雄性生殖腺或器官；和感觉器官。用于研究进行性骨化性纤维发育不良。该基因的人类直系同源物与进行性骨化性纤维发育不良有关。与人类 ACVR1（激活素 A 受体 1 型）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables activin binding activity; transforming growth factor beta binding activity; and transmembrane receptor protein serine/threonine kinase activity. Involved in heart development; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; and positive regulation of nitrogen compound metabolic process. Acts upstream of or within several processes, including chordate embryonic development; circulatory system development; and gastrulation. Located in apical part of cell. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; limb; male reproductive gland or organ; and sensory organ. Used to study fibrodysplasia ossificans progressiva. Human ortholog(s) of this gene implicated in fibrodysplasia ossificans progressiva. Orthologous to human ACVR1 (Activin A receptor type 1). [provided by Alliance of Genome Resources, Apr 2022]

Acvr1 基因产物(5)

mRNA Protein Name
NM_001355049.1 NP_001341978.1 activin receptor type-1 precursor
NM_007394.3 NP_031420.2 activin receptor type-1 precursor
NM_001355048.1 NP_001341977.1 activin receptor type-1 precursor
NM_001110204.1 NP_001103674.1 activin receptor type-1 precursor
NM_001110205.1 NP_001103675.1 activin receptor type-1 precursor

Acvr1 蛋白结构

Activin_recp

Activin_recp: pfam01064 (32 - 102)

TGF_beta_GS

TGF_beta_GS: pfam08515 (178 - 205)

STKc_ACVR1_ALK1

STKc_ACVR1_ALK1: cd14142 (201 - 498)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 509 a.a.
蛋白主名 其他名称

activin receptor type-1

TGF-B superfamily receptor type I

TSK-7L

TSR-I

activin receptor type I

serine/threonine-protein kinase receptor R1

重组 Acvr1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75539 ACVR1 Protein, Mouse (HEK293, His-hFc) P37172 (M1-E123) ≥95%

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-109179 Itacnosertib Inhibitor 99.77% Phase 2
Pre-clinical Phase
生物活性分子 (10)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-109179A Itacnosertib (hydrocholide) Inhibitor 98.98% 否
HY-RS00236 ACVR1 Human Pre-designed siRNA Set A / 否
HY-RS00237 Acvr1 Mouse Pre-designed siRNA Set A / 否
HY-RS00238 Acvr1 Rat Pre-designed siRNA Set A / 否
HY-RS00239 ACVR1B Human Pre-designed siRNA Set A / 否
HY-RS00240 Acvr1b Mouse Pre-designed siRNA Set A / 否
HY-RS00241 Acvr1b Rat Pre-designed siRNA Set A / 否
HY-RS00242 ACVR1C Human Pre-designed siRNA Set A / 否
HY-RS00243 Acvr1c Mouse Pre-designed siRNA Set A / 否
HY-RS00244 Acvr1c Rat Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Acvr1 NCBI NCBI:90
Canis familiaris Acvr1 NCBI NCBI:478757
Macaca fascicularis Acvr1 NCBI NCBI:102134051
Rattus norvegicus Acvr1 NCBI NCBI:79558
Macaca mulatta Acvr1 NCBI NCBI:697935
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