OSBPL6 - oxysterol binding protein like 6 Gene

中文名称：氧固醇结合蛋白样 6

种属: Homo sapiens

同用名: ORP6

基因 ID: 114880 | 基因类型: protein coding

关于 OSBPL6

Cytogenetic location: 2q31.2 Genomic coordinates (GRCh38): 2:178,193,774-178,402,893 (from NCBI)

This gene has 9 transcripts (splice variants), 219 orthologues and 11 paralogues. Broad expression in brain (RPKM 4.0), skin (RPKM 2.6) and 21 other tissues.

功能概要

该基因编码氧固醇结合蛋白 (OSBP) 家族的成员，该家族是一组细胞内脂质受体。大多数成员包含一个 N 端 pleckstrin 同源结构域和一个高度保守的 C 端 OSBP 样甾醇结合结构域。已经鉴定出编码不同亚型的转录变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

OSBPL6 基因产物(5)

mRNA	Protein	Name
NM_001201480.2	NP_001188409.1	oxysterol-binding protein-related protein 6 isoform c
NM_001201481.2	NP_001188410.1	oxysterol-binding protein-related protein 6 isoform d
NM_001201482.2	NP_001188411.1	oxysterol-binding protein-related protein 6 isoform e
NM_032523.4	NP_115912.1	oxysterol-binding protein-related protein 6 isoform a
NM_145739.3	NP_665682.1	oxysterol-binding protein-related protein 6 isoform b

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	22190034	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in regulation of cholesterol transport	IMP IMP: 通过突变表型推断	26941018	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytosol	IDA IDA: 通过直接分析推断	14593528	GOA
located in early endosome membrane	IDA IDA: 通过直接分析推断	26941018	GOA
located in endoplasmic reticulum membrane	IDA IDA: 通过直接分析推断	26941018	GOA
located in nuclear membrane	IDA IDA: 通过直接分析推断	14593528	GOA
located in perinuclear endoplasmic reticulum	IDA IDA: 通过直接分析推断	14593528	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	14593528	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

OSBPL6 蛋白结构

PH_8

Oxysterol_BP

0
200
400
600
800
934 a.a.

蛋白主名

其他名称

oxysterol-binding protein-related protein 6

ORP-6

OSBPL6 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属间	OSBPL6	Q9BZF3	ORF	Human immunodeficiency virus	Q9Q2G4	Pull Down	22190034

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Rhizomelic Chondrodysplasia Punctata, Type 3

Rhizomelic Chondrodysplasia Punctata Type 3	RCDP3
Alkyldihydroxyacetonephosphate Synthase Deficiency	Alkylglycerone-Phosphate Synthase Deficiency
Agps Deficiency	Rhizomelic Chondrodysplasia Punctata 3
Chondrodysplasia Punctata, Rhizomelic, Type 3

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09843	OSBPL6 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	OSBPL6	VGNC	VGNC:44156
Macaca mulatta	OSBPL6	VGNC	VGNC:75627
Bos taurus	OSBPL6	VGNC	VGNC:32464
Rattus norvegicus	OSBPL6	RGD	RGD:1308887
Felis catus	OSBPL6	VGNC	VGNC:63981
Mus musculus	OSBPL6	MGD	MGI:2139014

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