2. Gene
  3. Ang - angiogenin, ribonuclease, RNase A family, 5 Gene

Ang - angiogenin, ribonuclease, RNase A family, 5 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Ang1; Rnase5; Rnase5a

基因 ID: 11727 | 基因类型: protein coding

关于 Ang

功能概要

This gene encodes a member of the pancreatic ribonuclease A superfamily and is a potent inducer of neovascularization. The encoded protein is a secreted multifunctional tRNA-specific ribonuclease that promotes angiogenesis in response to angiogenetic stimuli such as hypoxia, mediates stress-induced translational repression by cleaving cellular tRNAs, stimulates cell proliferation by mediating rRNA transcription in prostate Cancer cells, and is involved in neurite pathfinding. This gene resides in a cluster of highly related genes. It shares dual promoters and 5' exons with the ribonuclease, RNase A family 4 gene. Two alternatively spliced variants, with different 5' exons but the same coding exon, have been identified. Multiple pseudogenes have been found for this gene. [provided by RefSeq, Jun 2009]

Ang 基因产物(2)

mRNA Protein Name
NM_001161731.3 NP_001155203.1 angiogenin precursor
NM_007447.4 NP_031473.1 angiogenin precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA nuclease activity IDA
IDA: 通过直接分析推断
8448182 MGI
enables tRNA-specific ribonuclease activity IDA
IDA: 通过直接分析推断
24752898 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in antibacterial humoral response IDA
IDA: 通过直接分析推断
12548285 MGI
involved in antifungal humoral response IDA
IDA: 通过直接分析推断
12548285 MGI
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
IDA: 通过直接分析推断
12548285 MGI
involved in cellular response to osmotic stress IDA
IDA: 通过直接分析推断
24752898 MGI
involved in defense response to Gram-positive bacterium IDA
IDA: 通过直接分析推断
12548285 MGI
involved in hematopoietic stem cell proliferation IMP
IMP: 通过突变表型推断
27518564 MGI
involved in innate immune response IDA
IDA: 通过直接分析推断
12548285 MGI
involved in negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
24752898 MGI
involved in negative regulation of cellular senescence IDA
IDA: 通过直接分析推断
33758201 MGI
involved in negative regulation of translation in response to stress IMP
IMP: 通过突变表型推断
27518564 MGI
involved in rRNA transcription IDA
IDA: 通过直接分析推断
33758201 MGI
involved in rRNA transcription IMP
IMP: 通过突变表型推断
27518564 MGI
involved in response to yeast IDA
IDA: 通过直接分析推断
12548285 MGI
involved in tRNA destabilization IDA
IDA: 通过直接分析推断
33986151 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
33758201 MGI
located in growth cone IDA
IDA: 通过直接分析推断
17468498 MGI
located in neuronal cell body IDA
IDA: 通过直接分析推断
17468498 MGI
is active in nucleus IDA
IDA: 通过直接分析推断
33758201 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

angiogenin

angiogenin, ribonuclease A family, member 1

angiogenin-1

ribonuclease 5

相关产品

Approval
生物活性分子 (8)
目录号 产品名 作用方式
纯度 是否罕见病
HY-13948 Angiotensin II human 99.98% 否
HY-13948A Angiotensin II human acetate 99.81% 否
HY-B0561 Spironolactone 99.63% 是
HY-B0202 Irbesartan 99.68% 是
HY-B0935 Benzyl benzoate Inhibitor 99.94% 是
HY-13948B Angiotensin II human TFA 98.84% 否
HY-B0202A Irbesartan hydrochloride / 否
HY-B0202R Irbesartan (Standard) / 否
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-P99116 Faricimab Inhibitor 97.97% 否
Clinical Phase
生物活性分子 (4)
目录号 产品名 作用方式
纯度 Phase
HY-137455 Terevalefim Activator 99.89% Phase 3
HY-P4073 ANG1005 98.83% Phase 3
HY-109041 Razuprotafib 98.0% Phase 2
HY-147243 Ansornitinib Inhibitor 98.04% Phase 2
抗体抑制剂 (4)
目录号 产品名 作用方式
纯度 Phase
HY-P99546 Trebananib Inhibitor ≥99.0% Phase 3
HY-P99330 Vanucizumab Inhibitor 95.12% Phase 2
HY-P99510 Zansecimab Inhibitor ≥95.0% Phase 2
HY-P99036 Nesvacumab Inhibitor 99.11% Phase 1
Pre-clinical Phase
生物活性分子 (51)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12403 Talfirastide 99.91% 是
HY-P0216 A 779 Antagonist 99.12% 否
HY-15778 AVE 0991 Agonist 99.91% 否
HY-15477 YS-49 99.80% 否
HY-P1236 Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse Inhibitor 99.46% 否
HY-N0515 Ophiopogonin D 99.80% 否
HY-151483 TK-129 Inhibitor ≥98.0% 否
HY-12403A Talfirastide acetate 99.77% 是
HY-P3136 TRV055 99.75% 否
HY-168438 ERBB agonist-1 99.16% 否
HY-P2983 Angiotensin-converting enzyme / 否
HY-P3136A TRV055 hydrochloride Agonist 99.97% 否
HY-N7665 Prosaikogenin G 98.35% 否
HY-13948F1 Angiotensin II human, FAM-labeled Activator 99.53% 否
HY-15778A AVE 0991 sodium salt Agonist 99.47% 否
HY-13948F Biotin-Ahx-Angiotensin II human 99.96% 否
HY-15477A YS-49 monohydrate 99.71% 否
HY-P1415A Norleual TFA 99.93% 否
HY-N2666 5α-Hydroxycostic acid Inhibitor 95.03% 否
HY-P10933 PRO20 Antagonist 98.12% 否
HY-13948BS Angiotensin II human-13C6,15N TFA 98.11% 否
HY-135795 1-Cyclohexyl-3-dodecyl urea Inhibitor 98.0% 否
HY-16707 CH 5450 Inhibitor 98.19% 否
HY-P1236A Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse TFA Inhibitor 99.36% 否
HY-RS00684 ANG Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-102093A ZD 7155 / 否
HY-103247 EMD 66684 Antagonist / 否
HY-121313 Embusartan Antagonist / 否
HY-129412 A-74273 Inhibitor / 否
HY-131162 Chymase Activator / 否
HY-142694 DCN1-UBC12-IN-2 Inhibitor / 否
HY-160043 AL6 aptamer sodium / 否
HY-162729 LSD1-IN-34 Inhibitor / 否
HY-163859 LSD1-IN-33 Inhibitor / 否
HY-169026 DCN1-IN-2 Inhibitor / 否
HY-172698 DSPE-PEG1000-ANG / 否
HY-172699 DSPE-PEG2000-ANG / 否
HY-172699A DSPE-PEG3400-ANG / 否
HY-172700 DSPE-PEG5000-ANG / 否
HY-B0202S2 Irbesartan-d6-1 / 否
HY-P10597 Angiotensin II type 1 receptor (181-187) Activator / 否
HY-P10777 ANG1009 / 否
HY-P1415 Norleual / 否
HY-P3545 5-Valine-angiotensin I Activator / 否
HY-W717329 EC33 Inhibitor / 否
HY-167886 GA 0113 Antagonist / 否
HY-B0202AS Irbesartan-d7 hydrochloride / 否
HY-B0202S3 Irbesartan-d7 / 否
HY-RS16832 Ang Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23274 Ang Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24191 Agt Rat Pre-designed siRNA Set A Pre-designed Set / 否
抗体抑制剂 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P991415 ASKG-712 Antagonist / 否
HY-P991663 AMG-780 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ang NCBI NCBI:283
Canis familiaris Ang NCBI NCBI:102153970
Macaca fascicularis Ang NCBI NCBI:102118768
Canis lupus familiaris Ang NCBI
Rattus norvegicus Ang NCBI NCBI:305843
Macaca mulatta Ang NCBI
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