Angiotensin II human TFA  (Synonyms: Angiotensin II TFA; Ang II TFA; DRVYIHPF TFA)

Angiotensin II human (Angiotensin II) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human TFA induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human TFA also induces apoptosis. Angiotensin II human TFA induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway^[1][2][3][4].

Angiotensin II human (Ang II) 的大部分已知作用均由 AT1 受体介导，AT2 受体有助于调节血压和肾功能^[1]。
Angiotensin II human 通过多种作用提高血压 (BP)，最重要的作用是血管收缩、交感神经刺激、醛固酮生物合成增加和肾脏作用。血管紧张素 II 的其他人体作用包括诱导血管平滑肌细胞的生长、细胞迁移和有丝分裂，增加成纤维细胞中 I 型和 III 型胶原蛋白的合成，导致血管壁和心肌增厚以及纤维化。这些作用由 1 型 Ang II 受体 (AT₁)介导^[2]。
Angiotensin II (1 nM) TFA 在 Matrigel 测定中诱导 LOX-1 和 VEGF 的表达，并增强人冠状动脉内皮细胞的毛细血管形成。抗 LOX-1 抗体烟酰胺腺嘌呤抑制血管紧张素 II 介导的 LOX-1 和 VEGF 表达、毛细血管形成、细胞内活性氧的产生和 p38 磷酸化以及 p44/42 丝裂原活化蛋白激酶二核苷酸磷酸氧化酶抑制剂夹竹桃麻素和 Ang II 1 型受体阻滞剂氯沙坦，但不是 Ang II 2 型受体阻滞剂 PD123319^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Angiotensin II human TFA (5 mL 1 nM；腹膜内注射；200-250 克 Sprague-Dawley 大鼠) 诱导显著的中性粒细胞募集，在 4 小时时达到最大，并在 24 小时时消退^[4]。
为了区分对高血压发病机制至关重要的 AT₁ 受体群，将渗透性微型泵皮下植入每只动物体内，以注入 Angiotensin II human TFA (1000 ng/kg/min) 连续4周。Angiotensin II human TFA 通过激活肾脏中的 AT₁ 受体促进钠重吸收引起高血压^[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1160.20

C₅₂H₇₂F₃N₁₃O₁₄

2761969-44-0

固体

White to off-white

DRVYIHPF

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture and light, under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

• [1]. de Gasparo M, et al. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev. 2000 Sep;52(3):415-72.  [Content Brief]

  [2]. Fyhrquist F, et al. Role of angiotensin II in blood pressure regulation and in the pathophysiology of cardiovascular disorders. J Hum Hypertens. 1995 Nov;9 Suppl 5:S19-24.  [Content Brief]

  [3]. Hu C, et al. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway. Hypertension. 2007;50(5):952-957.  [Content Brief]

  [4]. Nabah YN, et al. Angiotensin II induces neutrophil accumulation in vivo through generation and release of CXC chemokines. Circulation. 2004;110(23):3581-3586.  [Content Brief]

  [5]. Crowley SD, et al. Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17985-90.  [Content Brief]