2. Gene
  3. CLIC1 - chloride intracellular channel 1 Gene

CLIC1 - chloride intracellular channel 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：氯离子胞内通道 1

种属: Homo sapiens

同用名: G6; CL1C1; NCC27; CLCNL1

基因 ID: 1192 | 基因类型: protein coding

关于 CLIC1

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,730,581-31,737,318 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 249 orthologues and 14 paralogues. Ubiquitous expression in placenta (RPKM 110.8), bone marrow (RPKM 106.5) and 25 other tissues.

功能概要

氯离子通道是一组不同的蛋白质，可调节基本细胞过程，包括稳定细胞膜电位、跨上皮转运、维持细胞内 pH 值和调节细胞体积。氯离子细胞内通道 1 是 p64 家族的成员；该蛋白质主要定位于细胞核并表现出核和质膜氯离子通道活性。[RefSeq 提供，2008 年 7 月]

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008]

CLIC1 基因产物(3)

mRNA Protein Name
NM_001287593.1 NP_001274522.1 chloride intracellular channel protein 1
NM_001287594.3 NP_001274523.1 chloride intracellular channel protein 1
NM_001288.6 NP_001279.2 chloride intracellular channel protein 1

CLIC1 蛋白结构

GST_N_3

GST_N_3: Glutathione S-transferase, N-terminal domain (24 - 86)

GST_C_2

GST_C_2: Glutathione S-transferase, C-terminal domain (127 - 210)

  • 0
  • 100
  • 200
  • 241 a.a.
蛋白主名 其他名称

chloride intracellular channel protein 1

RNCC protein

重组 CLIC1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7840 CLIC1 Protein, Human (His) O00299 (M1-K241) ≥95%
HY-P7840A CLIC1 Protein, Human (N-His) O00299 (A2-K241) ≥95%

关联疾病

疾病名称 别名
Intrahepatic Gall Duct Cancer

Malignant Neoplasm Of Intrahepatic Bile Ducts

Malignant Neoplasm Of Intrahepatic Gall Duct

Ca Intrahepatic Bile Ducts

Malignant Neoplasm Of Intrahepatic Biliary Passages

Intrahepatic Bile Duct Carcinoma
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12693A (Rac)-Methylindazone / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus CLIC1 MGD MGI:2148924
Rattus norvegicus CLIC1 RGD RGD:1303043
Bos taurus CLIC1 VGNC VGNC:27439
Felis catus CLIC1 VGNC VGNC:60959
Others CLIC1 NCBI
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