1. Gene
  2. Bcl2a1a - B cell leukemia/lymphoma 2 related protein A1a Gene

Bcl2a1a - B cell leukemia/lymphoma 2 related protein A1a Gene

中文名称:B细胞白血病/淋巴瘤2 相关蛋白A1 a

种属: Mus musculus

同用名: A1; Bfl-1; Hbpa1; Bcl2a1

基因 ID: 12044 | 基因类型: protein coding

关于 Bcl2a1a

Chromosome 9: 88,838,953-88,844,472 forward strand.GRCm39:CM001002.3

This gene has 1 transcript (splice variant), 112 orthologues, 10 paralogues and is associated with 5 phenotypes. Biased expression in spleen adult (RPKM 7.1), thymus adult (RPKM 4.6) and 13 other tissues.

功能概要

预测该基因编码的蛋白能够实现蛋白质异二聚化活性和蛋白质同二聚化活性。参与细胞凋亡过程的负调控。在 B 细胞稳态和 B 细胞凋亡过程的负调节的上游或内部起作用。预计位于细胞质中。预计在线粒体外膜中有活性。以多种结构表达,包括骨骼;中枢神经系统;心;淋巴系统;和呼吸系统。与人类 BCL2A1(BCL2 相关蛋白 A1)同源。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable protein heterodimerization activity and protein homodimerization activity. Involved in negative regulation of apoptotic process. Acts upstream of or within B cell homeostasis and negative regulation of B cell apoptotic process. Predicted to be located in cytoplasm. Predicted to be active in mitochondrial outer membrane. Is expressed in several structures, including bone; central nervous system; heart; hemolymphoid system; and respiratory system. Orthologous to human BCL2A1 (BCL2 related protein A1). [provided by Alliance of Genome Resources, Apr 2022]

Bcl2a1a 基因产物(1)

mRNA Protein Name
NM_009742.3 NP_033872.1 bcl-2-related protein A1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11888890 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of B cell apoptotic process IDA
IDA: 通过直接分析推断
14625542 MGI
acts upstream of or within B cell homeostasis IDA
IDA: 通过直接分析推断
12928432 MGI
acts upstream of or within negative regulation of B cell apoptotic process IDA
IDA: 通过直接分析推断
14625542 MGI
involved in negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
11888890 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Bcl2a1a 蛋白结构

BCL

BCL: smart00337 (36 - 139)

  • 0
  • 100
  • 172 a.a.
蛋白主名 其他名称

bcl-2-related protein A1

A1-A

hemopoietic-specific early response protein

protein BFL-1

Bcl2a1a 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Bcl2a1 Q07440 BID Homo sapiens P55957
SPR
15694340
种属内
Bcl2a1 Q07440 Bmf Mus musculus Q91ZE9 18462686
种属内
Bcl2a1 Q07440 Bmf Mus musculus Q91ZE9
ITC
18462686
种属内
Bcl2a1 Q07440 Bbc3 Mus musculus Q99ML1
ITC
18462686
种属内
Bcl2a1 Q07440 Bbc3 Mus musculus Q99ML1 18462686
种属内
Bcl2a1 Q07440 Bid Mus musculus P70444
ITC
18462686
种属内
Bcl2a1 Q07440 Bid Mus musculus P70444 18462686
种属内
Bcl2a1 Q07440 Bak1 Mus musculus O08734
ITC
18462686
种属内
Bcl2a1 Q07440 Bak1 Mus musculus O08734 18462686
种属间: 跨种属相互作用 种属内: 同种属相互作用