2. Gene
  3. Bmpr2 - bone morphogenetic protein receptor, type II (serine/threonine kinase) Gene

Bmpr2 - bone morphogenetic protein receptor, type II (serine/threonine kinase) Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：骨形态发生蛋白受体， II 型 ( 丝氨酸/苏氨酸激酶)

种属: Mus musculus

同用名: BMP-2; BRK-3; BMPR-2; BMPRII; BMPR-II; Gm20272; 2610024H22Rik

基因 ID: 12168 | 基因类型: protein coding

关于 Bmpr2

Chromosome 1: 59,802,559-59,918,173 forward strand.GRCm39:CM000994.3

This gene has 3 transcripts (splice variants), 265 orthologues, 11 paralogues and is associated with 44 phenotypes. Broad expression in lung adult (RPKM 22.1), frontal lobe adult (RPKM 8.3) and 19 other tissues.

功能概要

该基因编码一种丝氨酸/苏氨酸激酶，作为骨形态发生蛋白 (BMP) 的受体发挥作用。编码的蛋白质是一种 II 型受体，它结合细胞外 BMP，并在细胞膜上形成两种 II 型和两种 I 型受体的复合物。该复合物向下游发出信号以激活 SMAD 转录调节因子。这种信号在胚胎发育过程中很重要。该基因的突变可导致肺动脉高压。 [RefSeq 提供，2013 年 3 月]

This gene encodes a serine/threonine kinase that functions as a receptor for bone morphogenetic proteins (BMPs). The encoded protein is a type II receptor that binds extracellular BMPs and forms a complex of two type II and two type I receptors at the cell membrane. This complex signals downstream to activate SMAD transcriptional regulators. This signaling is important during embryonic development. Mutations in this gene can cause pulmonary hypertension. [provided by RefSeq, Mar 2013]

Bmpr2 基因产物(1)

mRNA Protein Name
NM_007561.4 NP_031587.1 bone morphogenetic protein receptor type-2 precursor

Bmpr2 蛋白结构

Activin_recp

Activin_recp: pfam01064 (45 - 126)

STKc_BMPR2_AMHR2

STKc_BMPR2_AMHR2: cd14054 (206 - 503)

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  • 1038 a.a.
蛋白主名 其他名称

bone morphogenetic protein receptor type-2

BMP type II receptor

BMP type-2 receptor

bone morphogenic protein receptor, type II (serine/threonine kinase)

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-15897 LDN-212854 Inhibitor 99.70% 否
HY-154970A BMPR2-IN-1 TFA Inhibitor 99.40% 否
HY-154970 BMPR2-IN-1 Inhibitor / 否
HY-RS01552 BMPR2 Human Pre-designed siRNA Set A / 否
HY-RS01553 Bmpr2 Mouse Pre-designed siRNA Set A / 否
HY-RS01554 Bmpr2 Rat Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Bmpr2 NCBI NCBI:659
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