2. Gene
  3. Col1a2 - collagen, type I, alpha 2 Gene

Col1a2 - collagen, type I, alpha 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: oim; Cola2; Cola-2; Col1a-2

基因 ID: 12843 | 基因类型: protein coding

关于 Col1a2

功能概要

This gene encodes the alpha-2 subunit of the fibril-forming type I Collagen, the most abundant protein of bone, skin and tendon extracellular matrices. The encoded protein, in association with alpha-1 subunit, forms heterotrimeric type I procollagen that undergoes proteolytic processing during fibril formation. Mice harboring certain mutations in the encoded gene exhibit symptoms of moderate to severe forms of osteogenesis imperfecta. [provided by RefSeq, Dec 2015]

Col1a2 基因产物(1)

mRNA Protein Name
NM_007743.3 NP_031769.2 collagen alpha-2(I) chain preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables SMAD binding IPI
IPI: 通过物理相互作用推断
14559231 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
7629088 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within bone mineralization IMP
IMP: 通过突变表型推断
22910579 MGI
acts upstream of or within cellular response to amino acid stimulus IDA
IDA: 通过直接分析推断
20548288 MGI
acts upstream of or within collagen metabolic process IMP
IMP: 通过突变表型推断
22910579 MGI
acts upstream of or within extracellular matrix assembly IMP
IMP: 通过突变表型推断
22910579 MGI
acts upstream of or within protein heterotrimerization IDA
IDA: 通过直接分析推断
9213002 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of collagen trimer IDA
IDA: 通过直接分析推断
8686743 MGI
part of collagen type I trimer IDA
IDA: 通过直接分析推断
7825727 MGI
located in collagen-containing extracellular matrix IDA
IDA: 通过直接分析推断
34368841 MGI
located in extracellular space IDA
IDA: 通过直接分析推断
20053668 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

collagen alpha-2(I) chain

alpha-2 type I collagen

collagen COL1A2

procollagen, type I, alpha 2

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02971 COL1A2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20147 Col1a2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26651 Col1a2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Col1a2 NCBI NCBI:1278
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