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  2. SGPP2 - sphingosine-1-phosphate phosphatase 2 Gene

SGPP2 - sphingosine-1-phosphate phosphatase 2 Gene

中文名称:1-磷酸鞘氨醇磷酸酶 2

种属: Homo sapiens

同用名: SPP2; SPPase2

基因 ID: 130367 | 基因类型: protein coding

关于 SGPP2

Cytogenetic location: 2q36.1 Genomic coordinates (GRCh38): 2:222,423,988-222,562,621 (from NCBI)

This gene has 1 transcript (splice variant), 204 orthologues and 3 paralogues. Broad expression in thyroid (RPKM 13.7), esophagus (RPKM 12.0) and 18 other tissues.

功能概要

该基因编码的蛋白质是一种跨膜蛋白,可降解生物活性信号分子鞘氨醇 1-磷酸。编码的蛋白质在炎症反应期间被诱导,并已被证明被 microRNA-31 肿瘤抑制因子下调。已发现该基因编码不同亚型的可变剪接变体。[RefSeq 提供,2016 年 3 月]

The protein encoded by this gene is a transmembrane protein that degrades the bioactive signaling molecule sphingosine 1-phosphate. The encoded protein is induced during inflammatory responses and has been shown to be downregulated by the microRNA-31 tumor suppressor. Alternative splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016]

SGPP2 基因产物(3)

mRNA Protein Name
NM_001320833.2 NP_001307762.1 sphingosine-1-phosphate phosphatase 2 isoform b
NM_001320834.2 NP_001307763.1 sphingosine-1-phosphate phosphatase 2 isoform b
NM_152386.4 NP_689599.2 sphingosine-1-phosphate phosphatase 2 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables sphingosine-1-phosphate phosphatase activity IDA
IDA: 通过直接分析推断
12411432 GOA
enables sphingosine-1-phosphate phosphatase activity IMP
IMP: 通过突变表型推断
27059959 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in sphingosine metabolic process IDA
IDA: 通过直接分析推断
12411432 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
12411432 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SGPP2 蛋白结构

PAP2

PAP2: PAP2 superfamily (121 - 233)

  • 0
  • 100
  • 200
  • 300
  • 399 a.a.
蛋白主名 其他名称

sphingosine-1-phosphate phosphatase 2

sphingosine 1-phosphate phosphohydrolase 2

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SGPP2 RGD RGD:1565739
Canis familiaris SGPP2 VGNC VGNC:57395
Bos taurus SGPP2 VGNC VGNC:54481
Felis catus SGPP2 VGNC VGNC:65084
Mus musculus SGPP2 MGD MGI:3589109
Macaca mulatta SGPP2 VGNC VGNC:77278