2. Gene
  3. Dab1 - disabled 1 Gene

Dab1 - disabled 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: scm; scr; yot; scrambler; C630028C02Rik

基因 ID: 13131 | 基因类型: protein coding

关于 Dab1

功能概要

Predicted to enable phosphatidylinositol 3-kinase binding activity. Involved in lateral motor column neuron migration. Acts upstream of or within several processes, including adult walking behavior; negative regulation of receptor signaling pathway via JAK-STAT; and nervous system development. Located in perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 37. Orthologous to human DAB1 (DAB adaptor protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Dab1 基因产物(6)

mRNA Protein Name
NM_001369046.1 NP_001355975.1 disabled homolog 1 isoform 2
NM_001369047.1 NP_001355976.1 disabled homolog 1 isoform 2
NM_001369048.1 NP_001355977.1 disabled homolog 1 isoform 3
NM_001369049.1 NP_001355978.1 disabled homolog 1 isoform 4
NM_010014.3 NP_034144.1 disabled homolog 1 isoform 1
NM_177259.4 NP_796233.2 disabled homolog 1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
10460257 MGI
enables signaling adaptor activity IDA
IDA: 通过直接分析推断
9009273 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within Golgi localization IMP
IMP: 通过突变表型推断
21111240 MGI
acts upstream of or within adult walking behavior IMP
IMP: 通过突变表型推断
8875886 MGI
acts upstream of astrocyte differentiation IMP
IMP: 通过突变表型推断
18848628 MGI
acts upstream of axonogenesis IGI
IGI: 通过遗传相互作用推断
21111240 MGI
acts upstream of axonogenesis IMP
IMP: 通过突变表型推断
21111240 MGI
acts upstream of cell adhesion IMP
IMP: 通过突变表型推断
15091337 MGI
acts upstream of cell surface receptor signaling pathway via JAK-STAT IMP
IMP: 通过突变表型推断
18848628 MGI
acts upstream of or within cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration IMP
IMP: 通过突变表型推断
15091337 MGI
acts upstream of or within cerebellum structural organization IMP
IMP: 通过突变表型推断
9338785 MGI
acts upstream of or within cerebral cortex cell migration IMP
IMP: 通过突变表型推断
15249135 MGI
acts upstream of or within cerebral cortex radially oriented cell migration IGI
IGI: 通过遗传相互作用推断
24210661 MGI
acts upstream of or within cerebral cortex radially oriented cell migration IMP
IMP: 通过突变表型推断
9338785 MGI
involved in cerebral cortex radially oriented cell migration IMP
IMP: 通过突变表型推断
9338784 MGI
acts upstream of or within dendrite development IGI
IGI: 通过遗传相互作用推断
14715136 MGI
acts upstream of or within dendrite development IMP
IMP: 通过突变表型推断
14715136 MGI
acts upstream of or within hippocampus development IMP
IMP: 通过突变表型推断
18477607 MGI
involved in lateral motor column neuron migration IMP
IMP: 通过突变表型推断
20711475 MGI
acts upstream of or within motor neuron migration IMP
IMP: 通过突变表型推断
15703280 MGI
acts upstream of or within negative regulation of astrocyte differentiation IMP
IMP: 通过突变表型推断
18848628 MGI
acts upstream of or within negative regulation of axonogenesis IGI
IGI: 通过遗传相互作用推断
21111240 MGI
acts upstream of or within negative regulation of axonogenesis IMP
IMP: 通过突变表型推断
21111240 MGI
acts upstream of or within negative regulation of cell adhesion IMP
IMP: 通过突变表型推断
15091337 MGI
acts upstream of or within negative regulation of receptor signaling pathway via JAK-STAT IMP
IMP: 通过突变表型推断
18848628 MGI
acts upstream of neuron differentiation IMP
IMP: 通过突变表型推断
18848628 MGI
acts upstream of or within neuron migration IGI
IGI: 通过遗传相互作用推断
11226314 MGI
acts upstream of or within neuron migration IMP
IMP: 通过突变表型推断
8875886 MGI
involved in neuron migration IMP
IMP: 通过突变表型推断
9338784 MGI
acts upstream of or within positive regulation of neuron differentiation IMP
IMP: 通过突变表型推断
18848628 MGI
acts upstream of or within positive regulation of protein kinase activity IGI
IGI: 通过遗传相互作用推断
12526740 MGI
acts upstream of or within radial glia guided migration of Purkinje cell IGI
IGI: 通过遗传相互作用推断
24210661 MGI
acts upstream of or within radial glia guided migration of Purkinje cell IMP
IMP: 通过突变表型推断
9338785 MGI
involved in radial glia guided migration of Purkinje cell IMP
IMP: 通过突变表型推断
9338784 MGI
acts upstream of or within radial glia-guided pyramidal neuron migration IMP
IMP: 通过突变表型推断
9338785 MGI
involved in reelin-mediated signaling pathway IMP
IMP: 通过突变表型推断
9338784 MGI
involved in regulation of synapse maturation IDA
IDA: 通过直接分析推断
27624722 MGI
involved in regulation of synapse maturation IMP
IMP: 通过突变表型推断
27624722 MGI
acts upstream of or within small GTPase-mediated signal transduction IMP
IMP: 通过突变表型推断
15062102 MGI
involved in ventral spinal cord development IEP
IEP: 通过表达模式推断
20711475 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cytoplasm IDA
IDA: 通过直接分析推断
9338785 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
24068831 MGI
located in perinuclear region of cytoplasm IGI
IGI: 通过遗传相互作用推断
14578885 MGI
is active in synapse IDA
IDA: 通过直接分析推断
24068831 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

disabled homolog 1

yotari

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03510 DAB1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS03840 DNAAF3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS09781 OMA1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19317 Dab1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25808 Dab1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Dab1 NCBI NCBI:1600
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