2. Gene
  3. Twist2 - twist basic helix-loop-helix transcription factor 2 Gene

Twist2 - twist basic helix-loop-helix transcription factor 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Dermo1; bHLHa39

基因 ID: 13345 | 基因类型: protein coding

关于 Twist2

功能概要

Enables DNA-binding transcription factor activity; chromatin binding activity; and protein domain specific binding activity. Involved in negative regulation of transcription, DNA-templated. Acts upstream of or within several processes, including face morphogenesis; negative regulation of cell differentiation; and negative regulation of macromolecule metabolic process. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; branchial arch; embryo mesenchyme; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in Barber-Say syndrome; ablepharon macrostomia syndrome; and focal dermal hypoplasia. Orthologous to human TWIST2 (twist family bHLH transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Twist2 基因产物(1)

mRNA Protein Name
NM_007855.3 NP_031881.1 twist-related protein 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
7589808 MGI
enables chromatin binding IDA
IDA: 通过直接分析推断
16831897 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
14654692 MGI
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
15030764 MGI
enables transcription factor binding IDA
IDA: 通过直接分析推断
14654692 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of cell population proliferation IMP
IMP: 通过突变表型推断
19090621 MGI
acts upstream of or within cornea development in camera-type eye IMP
IMP: 通过突变表型推断
20574024 MGI
acts upstream of or within embryonic cranial skeleton morphogenesis IGI
IGI: 通过遗传相互作用推断
15030764 MGI
acts upstream of or within face morphogenesis IMP
IMP: 通过突变表型推断
20574024 MGI
acts upstream of keratinocyte proliferation IMP
IMP: 通过突变表型推断
20574024 MGI
acts upstream of macrophage cytokine production IGI
IGI: 通过遗传相互作用推断
16831897 MGI
acts upstream of macrophage cytokine production IMP
IMP: 通过突变表型推断
16831897 MGI
acts upstream of myeloid cell differentiation IMP
IMP: 通过突变表型推断
19090621 MGI
acts upstream of or within negative regulation of DNA binding IDA
IDA: 通过直接分析推断
14654692 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
7589808 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
19090621 MGI
acts upstream of or within negative regulation of macrophage cytokine production IGI
IGI: 通过遗传相互作用推断
16831897 MGI
acts upstream of or within negative regulation of macrophage cytokine production IMP
IMP: 通过突变表型推断
16831897 MGI
acts upstream of or within negative regulation of molecular function IDA
IDA: 通过直接分析推断
15030764 MGI
acts upstream of or within negative regulation of myeloid cell differentiation IMP
IMP: 通过突变表型推断
19090621 MGI
acts upstream of or within negative regulation of osteoblast differentiation IMP
IMP: 通过突变表型推断
15030764 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16831897 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
14654692 MGI
acts upstream of or within negative regulation of tumor necrosis factor production IGI
IGI: 通过遗传相互作用推断
16831897 MGI
acts upstream of or within negative regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
16831897 MGI
acts upstream of or within osteoblast differentiation IMP
IMP: 通过突变表型推断
15030764 MGI
acts upstream of or within positive regulation of keratinocyte proliferation IMP
IMP: 通过突变表型推断
20574024 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
7589808 MGI
acts upstream of tumor necrosis factor production IGI
IGI: 通过遗传相互作用推断
16831897 MGI
acts upstream of tumor necrosis factor production IMP
IMP: 通过突变表型推断
16831897 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of transcription regulator complex IPI
IPI: 通过物理相互作用推断
7589808 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

twist-related protein 2

dermis-expressed protein 1

twist homolog 2

Twist2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Twist2 Q9D030 Runx2 Mus musculus Q08775
Anti Bait CoIP
20655471
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15282 TWIST2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21968 Twist2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28485 Twist2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Twist2 NCBI NCBI:117581
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