2. Gene
  3. Dpp4 - dipeptidylpeptidase 4 Gene

Dpp4 - dipeptidylpeptidase 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：二肽基肽酶4

种属: Mus musculus

同用名: Cd26; THAM; Dpp-4

基因 ID: 13482 | 基因类型: protein coding

关于 Dpp4

Chromosome 2: 62,160,417-62,242,575 reverse strand.GRCm39:CM000995.3

This gene has 6 transcripts (splice variants), 286 orthologues, 6 paralogues and is associated with 31 phenotypes. Biased expression in large intestine adult (RPKM 3.2), small intestine adult (RPKM 11.7) and 11 other tissues.

功能概要

预计该基因编码的蛋白具有多种功能，包括化学排斥活性；肽酶活性；和蛋白质同二聚化活性。在行为恐惧反应的上游或内部行动；运动探索行为；和精神运动行为。位于细胞间小管内。以多种结构表达，包括泌尿生殖系统；内耳;胚内体腔；肝;和原始心管。用于研究中东呼吸综合症。该基因的人类直系同源物与中东呼吸综合征和 2 型糖尿病有关。与人 DPP4（二肽基肽酶 4）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including chemorepellent activity; peptidase activity; and protein homodimerization activity. Acts upstream of or within behavioral fear response; locomotory exploration behavior; and psychomotor behavior. Located in intercellular canaliculus. Is expressed in several structures, including genitourinary system; inner ear; intraembryonic coelom; liver; and primitive heart tube. Used to study Middle East respiratory syndrome. Human ortholog(s) of this gene implicated in Middle East respiratory syndrome and type 2 diabetes mellitus. Orthologous to human DPP4 (Dipeptidyl Peptidase 4). [provided by Alliance of Genome Resources, Apr 2022]

Dpp4 基因产物(2)

mRNA Protein Name
NM_001159543.1 NP_001153015.1 dipeptidyl peptidase 4 isoform 2
NM_010074.3 NP_034204.1 dipeptidyl peptidase 4 isoform 1

Dpp4 蛋白结构

DPPIV_rep

DPPIV_rep: pfam18811 (35 - 55)

DPPIV_N

DPPIV_N: pfam00930 (101 - 471)

Peptidase_S9

Peptidase_S9: pfam00326 (552 - 756)

  • 0
  • 200
  • 400
  • 600
  • 760 a.a.
蛋白主名 其他名称

dipeptidyl peptidase 4

DPP IV

T-cell activation antigen CD26

dipeptidyl peptidase IV

thymocyte-activating molecule

重组 Dpp4 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75428 CD26/Dipeptidyl Peptidase 4 Protein, Mouse (HEK293, His) P28843 (S29-H760) ≥95%
HY-P75429 CD26/Dipeptidyl Peptidase 4 Protein, Mouse (HEK293, Fc) P28843 (S29-H760) ≥95%

相关产品

Approval
生物活性分子 (20)
目录号 产品名 作用方式
纯度 是否罕见病
HY-13749 Sitagliptin Inhibitor 99.76% 是
HY-10284 Linagliptin 99.91% 否
HY-10285 Saxagliptin Inhibitor 99.96% 是
HY-13749A Sitagliptin phosphate Inhibitor 99.85% 是
HY-15981 Omarigliptin Inhibitor / 否
HY-13749B Sitagliptin phosphate monohydrate Inhibitor 99.49% 是
HY-14806 Teneligliptin Inhibitor 99.85% 否
HY-A0023 Alogliptin Benzoate Inhibitor 99.99% 否
HY-A0023A Alogliptin Inhibitor 99.92% 否
HY-15408 Trelagliptin Inhibitor 99.54% 否
HY-14877 Anagliptin Inhibitor 99.91% 否
HY-14806B Teneligliptin hydrobromide hydrate Inhibitor 99.87% 否
HY-14806A Teneligliptin hydrobromide Inhibitor 99.99% 否
HY-15408A Trelagliptin succinate Inhibitor 99.96% 否
HY-16448 Saxagliptin hydrochloride Inhibitor 99.71% 是
HY-14892 Gemigliptin Inhibitor / 否
HY-108795A Albiglutide fragment TFA Agonist 99.12% 否
HY-14877A Anagliptin hydrochloride Inhibitor / 否
HY-108795 Albiglutide fragment Agonist / 否
HY-10285A Saxagliptin hydrate Inhibitor ≥99.0% 否
Clinical Phase
生物活性分子 (8)
目录号 产品名 作用方式
纯度 Phase
HY-117985B Evogliptin tartrate 99.71% Phase 4
HY-14806S Teneligliptin-d8 Inhibitor / Phase 4
HY-117985 Evogliptin / Phase 4
HY-112668 Retagliptin phosphate Inhibitor 99.89% Phase 3
HY-10286 Dutogliptin Inhibitor 99.32% Phase 3
HY-147257 Cofrogliptin Inhibitor 99.07% Phase 3
HY-10286A Dutogliptin tartrate Inhibitor / Phase 3
HY-12528 DBPR108 Inhibitor 98.75% Phase 1
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99466 Begelomab Inhibitor ≥95.0% Phase 3
Pre-clinical Phase
生物活性分子 (36)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P1141 GLP-1(9-36)amide Antagonist 99.78% 否
HY-14892A Gemigliptin tartrate Inhibitor 98.17% 否
HY-P2543 Neuropeptide Y (3-36) (human, rat) Agonist 96.95% 否
HY-112668A Retagliptin Inhibitor 98.30% 否
HY-147401 Sitagliptin fenilalanil Inhibitor 99.76% 否
HY-A0023AS1 Alogliptin-d3 Inhibitor 99.61% 否
HY-10284S Linagliptin-d4 99.62% 否
HY-124958 NDMC101 Inhibitor 99.59% 否
HY-A0023AS Alogliptin-13C,d3 Inhibitor / 否
HY-123377 Fotagliptin Inhibitor / 否
HY-123377A Fotagliptin benzoate Inhibitor 99.19% 否
HY-147401A Sitagliptin fenilalanil hydrochloride Inhibitor 98.94% 否
HY-10284S1 Linagliptin-13C,d3 / 否
HY-129736 P32/98 hemifumarate Inhibitor / 否
HY-129736A P32/98 Inhibitor / 否
HY-13749C (S)-Sitagliptin phosphate Inhibitor / 否
HY-13749S1 Sitagliptin-d4 hydrochloride / 否
HY-146455 DPP-4-IN-3 Inhibitor / 否
HY-146468 DPP-4/GPR119 modulator 1 / 否
HY-146469 DPP-4/GPR119 modulator 2 / 否
HY-14806S1 Teneligliptin-d4 Inhibitor / 否
HY-151383 DPP-4-IN-1 Inhibitor / 否
HY-151384 DPP-4-IN-2 Inhibitor / 否
HY-155027 DPP-4-IN-8 Inhibitor / 否
HY-155961 Antidiabetic agent 2 Inhibitor / 否
HY-157390 DPP-4-IN-9 Inhibitor / 否
HY-163332 MPO-IN-6 Inhibitor / 否
HY-N9725 16-Hydroxycleroda-3,13-dien-15,16-olide Inhibitor / 否
HY-P1141A GLP-1(9-36)amide TFA Antagonist / 否
HY-RS03963 DPP4 Human Pre-designed siRNA Set A / 否
HY-RS03964 Dpp4 Mouse Pre-designed siRNA Set A / 否
HY-RS03965 Dpp4 Rat Pre-designed siRNA Set A / 否
HY-13749AS Sitagliptin-d4 phosphate Inhibitor / 否
HY-13749D (Rac)-Sitagliptin Inhibitor / 否
HY-16656 BMS-767778 Inhibitor / 否
HY-N8134 2-Methoxy-5-acetoxy-fruranogermacr-1(10)-en-6-one Inhibitor / 否
抗体抑制剂 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P9805 Anti-MERS-3A1 mAb Inhibitor / 否
HY-P9806 Anti-MERS-D12 mAb Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Dpp4 NCBI NCBI:1803
Macaca fascicularis Dpp4 NCBI NCBI:102133935
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