1. NF-κB
    Metabolic Enzyme/Protease
  2. NF-κB
    Dipeptidyl Peptidase
  3. NDMC101

NDMC101 

目录号: HY-124958
产品使用指南

NDMC101 是一种有效的破骨细胞形成 (osteoclastogenesis) 抑制剂,通过下调 NFATc1 调控基因表达抑制破骨细胞分化。NDMC101 与 DPP4 底物相似,并且通过抑制 DPP4 而抑制早期 T 细胞激活的重要抑制剂。NDMC101 可用于骨疾病的研究,如类风湿关节炎、滑膜炎等。

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NDMC101 Chemical Structure

NDMC101 Chemical Structure

CAS No. : 1308631-40-4

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规格 价格 是否有货
5 mg ¥700 询问价格 & 货期
10 mg ¥1200 询问价格 & 货期
25 mg ¥2500 询问价格 & 货期
50 mg ¥4000 询问价格 & 货期
100 mg ¥6000 询问价格 & 货期

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NDMC101 is a potent osteoclastogenesis inhibitor and inhibits osteoclast differentiation via down-regulation of NFATc1-modulated gene expression. NDMC101 is similar to the DPP4 substrate and is a significant inhibitor of early T-cell activation via DPP4 inhibition. NDMC101can be used for study of bone disorders, such as rheumatoid arthritis, and synovial inflammation et al[1].

体外研究
(In Vitro)

NDMC101 (10-15 µM) inhibits RANKL-induced osteoclast differentiation of bone marrow-derived macrophages (BMDMs) and RAW 264.7 cells[1].
NDMC101 (15 µM) decreases RANKL-induced expression of the osteoclastogenic genes Nfatc1Acp5CtskOscarItgb3, and Dcstamp in BMDMs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

265.67

Formula

C₁₃H₉ClFNO₂

CAS 号
SMILES

OC1=C(C=CC=C1)C(NC2=CC=C(C=C2F)Cl)=O

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

Keywords:

NDMC101NDMC 101NDMC-101NF-κBDipeptidyl PeptidaseNuclear factor-κBNuclear factor-kappaBDPPBonerheumatoid arthritisosteoblastNSAIDRAW 264.7marrow-derived macrophagessynovial inflammationbone destruction,Inhibitorinhibitorinhibit

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NDMC101
目录号:
HY-124958
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