2. Metabolic Enzyme/Protease Apoptosis Immunology/Inflammation
  3. Dipeptidyl Peptidase TNF Receptor Interleukin Related
  4. DPP-4-IN-8

DPP-4-IN-8 (compound 27) 是一种有效的选择性 DPP4 抑制剂，Ki 为 0.96 μM。DPP-4-IN-8 可阻断 Caco-2 和 HepG-2 细胞中 DPP4 的二肽酶活性。DPP-4-IN-8 还剂量依赖性地抑制趋化因子肿瘤坏死因子-α (TNF-α)、白细胞介素 6 (IL-6) 和白细胞介素 1β (IL-1β) 的表达水平[1 ]。

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DPP-4-IN-8 Chemical Structure

DPP-4-IN-8 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

DPP-4-IN-8 相关抗体

Top Publications Citing Use of Products

查看 Dipeptidyl Peptidase 亚型特异性产品:

查看所有亚型
DPP-1 DPP-2 DPP-4 DPP-8 DPP-9

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DPP-4-IN-8 (compound 27) is a potent and selective DPP4 (dipeptidyl peptidase 4) inhibitor, with a Ki of 0.96 μM. DPP-4-IN-8 blocks the dipeptidase activity of DPP4 in both Caco-2 and HepG-2 cells. DPP-4-IN-8 also dose-dependently suppresses the expression levels of the chemokines tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β)[1].

IC50 & Target

DPP-4

0.96 μM (Ki)

IL-6

 

IL-1β

 

体外研究
(In Vitro)

DPP-4-IN-8 (compound 27) 对正常细胞无毒性，对癌细胞有微弱毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DPP-4-IN-8 相关抗体:
分子量

349.72

Formula

C16H12ClNO6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DPP-4-IN-8 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DPP-4-IN-8Dipeptidyl PeptidaseTNF ReceptorInterleukin RelatedDPPTumor Necrosis Factor ReceptorTNFRILCaco-2HepG-2Inhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-155027
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