COX8A - cytochrome c oxidase subunit 8A Gene

中文名称：细胞色素 c 氧化酶亚基 8A

种属: Homo sapiens

同用名: COX; COX8; VIII; COX8L; COX8-2; VIII-L; MC4DN15

基因 ID: 1351 | 基因类型: protein coding

关于 COX8A

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:63,974,620-63,976,543 (from NCBI)

This gene has 1 transcript (splice variant), 101 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in kidney (RPKM 159.8), colon (RPKM 143.7) and 25 other tissues.

功能概要

由该基因编码的蛋白质是呼吸链的末端酶，将电子从细胞色素 c 转移到分子氧，同时产生穿过线粒体内膜的质子电化学梯度。除了执行催化功能的 3 个线粒体编码亚基外，真核酶还包含核编码的较小亚基，数量从某些生物体中的 4 个到哺乳动物中的 10 个不等。已经提出核编码的亚基可能参与催化功能的调节。该基因编码核编码亚基之一。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is the terminal enzyme of the respiratory chain, coupling the transfer of electrons from cytochrome c to molecular oxygen, with the concomitant production of a proton electrochemical gradient across the inner mitochondrial membrane. In addition to 3 mitochondrially encoded subunits, which perform the catalytic function, the eukaryotic enzyme contains nuclear-encoded smaller subunits, ranging in number from 4 in some organisms to 10 in mammals. It has been proposed that nuclear-encoded subunits may be involved in the modulation of the catalytic function. This gene encodes one of the nuclear-encoded subunits. [provided by RefSeq, Jul 2008]

COX8A 基因产物(1)

mRNA	Protein	Name
NM_004074.3	NP_004065.1	cytochrome c oxidase subunit 8A, mitochondrial

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in mitochondrial membrane	IDA IDA: 通过直接分析推断	30030519	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

COX8A 蛋白结构

COX8

0
69 a.a.

蛋白主名

其他名称

cytochrome c oxidase subunit 8A, mitochondrial

cytochrome c oxidase polypeptide VIII-liver/heart

COX8A 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	COX8A	P10176	EDDM3B	Homo sapiens	P56851	Y2H Array	32296183
种属内	COX8A	P10176	EDDM3B	Homo sapiens	P56851	Validated Y2H	32296183
种属内	COX8A	P10176	EDDM3B	Homo sapiens	P56851	Y2H Prey Pooling	32296183
种属内	COX8A	P10176	MAGEA4	Homo sapiens	P43358	Y2H Prey Pooling	32296183
种属内	COX8A	P10176	MAGEA4	Homo sapiens	P43358	Validated Y2H	32296183
种属内	COX8A	P10176	MAGEA4	Homo sapiens	P43358	Y2H Array	32296183
种属内	COX8A	P10176	BATF	Homo sapiens	Q16520	Y2H Prey Pooling	32296183
种属内	COX8A	P10176	BATF	Homo sapiens	Q16520	Validated Y2H	32296183
种属内	COX8A	P10176	BATF	Homo sapiens	Q16520	Y2H Array	32296183
种属内	COX8A	P10176	NPM1	Homo sapiens	P06748	Y2H Prey Pooling	25416956
种属内	COX8A	P10176	NPM1	Homo sapiens	P06748	Validated Y2H	25416956
种属内	COX8A	P10176	NPM1	Homo sapiens	P06748	Y2H Array	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Mitochondrial Complex Iv Deficiency, Nuclear Type 15

MC4DN15

Mitochondrial Complex 4 Deficiency, Nuclear Type 15

Isolated Cytochrome C Oxidase Deficiency

Isolated Cox Deficiency

Isolated Mitochondrial Respiratory Chain Complex Iv Deficiency

Mitochondrial Complex Iv Deficiency, Nuclear Type 1

Cytochrome C Oxidase Deficiency	Mitochondrial Complex Iv Deficiency
Cox Deficiency	Cytochrome-C Oxidase Deficiency Disease
MC1DN4	Cytochrome-C Oxidase Deficiency
MC4DN1	Mitochondrial Complex I Deficiency, Nuclear Type 4
Complex 4 Mitochondrial Respiratory Chain Deficiency	Complex Iv Deficiency
Mitochondrial Complex 1 Deficiency, Nuclear Type 4	Nuclear Type Mitochondrial Complex I Deficiency 4
Deficiency Of Mitochondrial Respiratory Chain Complex4	MT-C4D
Complex Iv Mitochondrial Respiratory Chain Deficiency	Lethal Neonatal Cardiomyopathy Hypertrophic Due To Cytochrome C Oxidase Deficiency
Mitochondrial Complex Iv Deficiency, Nuclear, Type 1

Cardiomyopathy, Familial Hypertrophic, 4

Hypertrophic Cardiomyopathy 4	CMH4
Cardiomyopathy, Hypertrophic, 4	Cardiomyopathy, Familial Hypertrophic 4
Cardiomyopathy, Familial Hypertrophic, 4, Susceptibility To	Cardiomyopathy, Hypertrophic, Familial, Type 4

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03078	COX8A Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS22453	Cox8a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS28976	Cox8a Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	COX8A	VGNC	VGNC:107440
Mus musculus	COX8A	MGD	MGI:105959
Felis catus	COX8A	VGNC	VGNC:82003
Rattus norvegicus	COX8A	RGD	RGD:620638

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

COX8A - cytochrome c oxidase subunit 8A Gene

关于 COX8A

功能概要

COX8A 基因产物(1)

COX8A 蛋白结构

COX8A 蛋白互作信息

关联疾病

直系同源

热门区域

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COX8A - cytochrome c oxidase subunit 8A Gene

关于 COX8A

功能概要

COX8A 基因产物(1)

COX8A 蛋白结构

COX8A 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z