2. Gene
  3. CPA3 - carboxypeptidase A3 Gene

CPA3 - carboxypeptidase A3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：羧肽酶 A3

种属: Homo sapiens

同用名: MC-CPA

基因 ID: 1359 | 基因类型: protein coding

关于 CPA3

Cytogenetic location: 3q24 Genomic coordinates (GRCh38): 3:148,865,296-148,897,203 (from NCBI)

This gene has 2 transcripts (splice variants), 143 orthologues and 8 paralogues. Biased expression in gall bladder (RPKM 74.3), lung (RPKM 46.6) and 11 other tissues.

功能概要

该基因编码锌金属蛋白酶羧肽酶 A 家族的一个成员。编码的前原蛋白经过蛋白水解处理，产生成熟的蛋白酶，由肥大细胞释放，可能参与内源性蛋白质的降解和毒液相关肽的失活。该基因的表达可能在人类哮喘患者中升高。[RefSeq 提供，2015 年 11 月]

This gene encodes a member of the Carboxypeptidase A family of zinc metalloproteases. The encoded preproprotein is proteolytically processed to generate a mature protease that is released by mast cells and may be involved in the degradation of endogenous proteins and the inactivation of venom-associated peptides. Expression of this gene may be elevated in human asthma patients. [provided by RefSeq, Nov 2015]

CPA3 基因产物(1)

mRNA Protein Name
NM_001870.4 NP_001861.2 mast cell carboxypeptidase A preproprotein

CPA3 蛋白结构

Propep_M14

Propep_M14: Carboxypeptidase activation peptide (27 - 103)

Peptidase_M14

Peptidase_M14: Zinc carboxypeptidase (125 - 403)

  • 0
  • 100
  • 200
  • 300
  • 417 a.a.
蛋白主名 其他名称

mast cell carboxypeptidase A

carboxypeptidase A3 (mast cell)

关联疾病

疾病名称 别名
Thiopental Allergy

Penthiobarbital Allergy

Pentothiobarbital Allergy
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus
Anemia, X-Linked, With Or Without Neutropenia And/Or Platelet Abnormalities

X-Linked Dyserythropoietic Anemia

X-Linked Dyserythropoietic Anemia With Abnormal Platelets And Neutropenia

XLANP

Anemia, X-Linked, With/Without Neutropenia And/Or Platelet Abnormalities

X-Linked Anemia With/Without Neutropenia And/Or Platelet Abnormalities

Anemia Without Thrombocytopenia, X-Linked

XLAWT

Anemia X-Linked With Variable Neutropenia
Factitious Disorder

Munchausen Syndrome

Factitious Disorders

Münchausen Syndrome
Exercise-Induced Bronchoconstriction

Exercise-Induced Asthma

Asthma Exercise-Induced
Esophagitis, Eosinophilic, 1

Eosinophilic Esophagitis

EOE1

Esophagitis, Eosinophilic

Ee
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03082 CPA3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS03083 CPA4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CPA3 RGD RGD:2390
Mus musculus CPA3 MGD MGI:88479
Felis catus CPA3 VGNC VGNC:61113
Canis familiaris CPA3 VGNC VGNC:39544
Bos taurus CPA3 VGNC VGNC:27643
Macaca mulatta CPA3 VGNC VGNC:71456
Others CPA3 NCBI
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