2. Gene
  3. DGKK - diacylglycerol kinase kappa Gene

DGKK - diacylglycerol kinase kappa Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：二酰甘油激酶κ

种属: Homo sapiens

基因 ID: 139189 | 基因类型: protein coding

关于 DGKK

Cytogenetic location: Xp11.22 Genomic coordinates (GRCh38): X:50,365,409-50,470,825 (from NCBI)

This gene has 1 transcript (splice variant), 103 orthologues and 9 paralogues. Biased expression in adrenal (RPKM 2.2), brain (RPKM 0.3) and 1 other tissue.

功能概要

该基因编码的蛋白质是一种磷酸化甘油二酯，将其转化为磷脂酸的酶。编码的蛋白质是一种膜蛋白，被过氧化氢抑制。该基因的变异与尿道下裂有关。[RefSeq 提供，2011 年 3 月]

The protein encoded by this gene is an enzyme that phosphorylates diacylglycerol, converting it to phosphatidic acid. The encoded protein is a membrane protein and is inhibited by hydrogen peroxide. Variations in this gene have been associated with hypospadias. [provided by RefSeq, Mar 2011]

DGKK 基因产物(1)

mRNA Protein Name
NM_001013742.4 NP_001013764.1 diacylglycerol kinase kappa
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP-dependent diacylglycerol kinase activity IDA
IDA: 通过直接分析推断
16210324 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in diacylglycerol metabolic process IDA
IDA: 通过直接分析推断
16210324 GOA
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
16210324 GOA
involved in response to oxidative stress IDA
IDA: 通过直接分析推断
16210324 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
16210324 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

diacylglycerol kinase kappa

142 kDa diacylglycerol kinase

关联疾病

疾病名称 别名
Hypospadias

Hypospadias Familial

Familial Hypospadias
Nephrotic Syndrome, Type 7

Immunoglobulin-Mediated Membranoproliferative Glomerulonephritis

Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 7

NPHS7

Nephrotic Syndrome Type 7

Ig-Mediated Membranoproliferative Glomerulonephritis

Ig-Mediated Mpgn

Immunoglobulin-Mediated Mpgn

Nephrotic Syndrome, Type 7, With Membranoproliferative Glomerulonephritis

Hemolytic Uremic Syndrome, Atypical 7

Nephrotic Syndrome Type 7 With Membranoptoliferative Glomerulonephritis

Hemolytic Uremic Syndrome With Dgke Deficiency

Hus With Dgke Deficiency

Hemolytic Uremic Syndrome Atypical 7

AHUS7

Nephrotic Syndrome 7

Nephrotic Syndrome Type 7 With Membranoproliferative Glomerulonephritis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03722 DGKK Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus DGKK VGNC VGNC:56703
Mus musculus DGKK MGD MGI:3580254
Canis familiaris DGKK VGNC VGNC:39922
Felis catus DGKK VGNC VGNC:61462
Macaca mulatta DGKK VGNC VGNC:71823
Rattus norvegicus DGKK RGD RGD:1561510
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