2. Gene
  3. ASB11 - ankyrin repeat and SOCS box containing 11 Gene

ASB11 - ankyrin repeat and SOCS box containing 11 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含锚蛋白重复和 SOCS 盒 11

种属: Homo sapiens

基因 ID: 140456 | 基因类型: protein coding

关于 ASB11

Cytogenetic location: Xp22.2 Genomic coordinates (GRCh38): X:15,281,697-15,315,640 (from NCBI)

This gene has 4 transcripts (splice variants), 144 orthologues and 2 paralogues. Biased expression in heart (RPKM 11.7), stomach (RPKM 1.0) and 1 other tissue.

功能概要

由该基因编码的蛋白质是锚蛋白重复序列和含有 SOCS 盒 (ASB) 的蛋白质家族的成员。它们包含锚蛋白重复序列和 SOCS 框域。 SOCS 盒用于将细胞因子信号转导抑制因子 (SOCS) 蛋白及其结合伙伴与 elongin B 和 C 复合物偶联，可能靶向它们进行降解。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 1 月]

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

ASB11 基因产物(3)

mRNA Protein Name
NM_001012428.2 NP_001012428.1 ankyrin repeat and SOCS box protein 11 isoform b
NM_001201583.2 NP_001188512.1 ankyrin repeat and SOCS box protein 11 isoform c
NM_080873.3 NP_543149.1 ankyrin repeat and SOCS box protein 11 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ubiquitin-like ligase-substrate adaptor activity IDA
IDA: 通过直接分析推断
24337577 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in endoplasmic reticulum unfolded protein response IDA
IDA: 通过直接分析推断
31387940 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
31387940 GOA
involved in protein K11-linked ubiquitination IDA
IDA: 通过直接分析推断
38574733 GOA
involved in protein ubiquitination IDA
IDA: 通过直接分析推断
24337577 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Cul5-RING ubiquitin ligase complex IDA
IDA: 通过直接分析推断
31387940 GOA
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
24337577 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ASB11 蛋白结构

Ank_2

Ank_2: Ankyrin repeats (3 copies) (69 - 158)

Ank

Ank: Ankyrin repeat (165 - 191)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (200 - 282)

SOCS_box

SOCS_box: SOCS box (284 - 323)

  • 0
  • 100
  • 200
  • 300
  • 323 a.a.
蛋白主名 其他名称

ankyrin repeat and SOCS box protein 11

ASB-11

关联疾病

疾病名称 别名
Lacrimal Duct Obstruction

Blocked Lacrimal Canaliculus

Obstruction Of Lacrimal Canaliculus

Obstruction Of Lacrimal Ducts
Myiasis

Infestation By Fly Larvae

Infestation By Maggots

Maggot Infestation

Infestation By Larvae Of Flies

Infestation By Dermatobia

Infestation By Estrus Ovis

Infestation By Oestrus Ovis

Oestriasis

Oestrosis
Cockayne Syndrome B

Cockayne Syndrome Type 2

Cockayne Syndrome, Type B

Cockayne Syndrome Type Ii

CSB

Cockayne Syndrome 2

Cockayne Syndrome Type B

Ckn2

Cockayne Syndrome, Type Ii
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01060 ASB11 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus ASB11 VGNC VGNC:26188
Mus musculus ASB11 MGD MGI:1916104
Rattus norvegicus ASB11 RGD RGD:1566298
Felis catus ASB11 VGNC VGNC:59956
Canis familiaris ASB11 VGNC VGNC:38156
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