2. Gene
  3. ADPRH - ADP-ribosylarginine hydrolase Gene

ADPRH - ADP-ribosylarginine hydrolase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：ADP-核糖精氨酸水解酶

种属: Homo sapiens

同用名: ARH1; hARH1

基因 ID: 141 | 基因类型: protein coding

关于 ADPRH

Cytogenetic location: 3q13.33 Genomic coordinates (GRCh38): 3:119,579,492-119,589,945 (from NCBI)

This gene has 7 transcripts (splice variants), 191 orthologues and 1 paralogue. Ubiquitous expression in lung (RPKM 7.2), spleen (RPKM 6.0) and 25 other tissues.

功能概要

由该基因编码的酶在 ADP-核糖基化循环中催化从蛋白质精氨酸残基中去除单-ADP-核糖。与需要 DTT 才能发挥最大活性的大鼠和小鼠酶不同，人类酶不依赖于 DTT。已经描述了编码不同蛋白质同种型的可变剪接转录物变体。[RefSeq 提供，2014 年 5 月]

The enzyme encoded by this gene catalyzes removal of mono-ADP-ribose from arginine residues of proteins in the ADP-ribosylation cycle. Unlike the rat and mouse Enzymes that require DTT for maximal activity, the human enzyme is DTT-independent. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, May 2014]

ADPRH 基因产物(5)

mRNA Protein Name
NM_001125.4 NP_001116.1 ADP-ribosylarginine hydrolase isoform 1
NM_001291949.2 NP_001278878.1 ADP-ribosylarginine hydrolase isoform 1
NM_001291950.2 NP_001278879.1 ADP-ribosylarginine hydrolase isoform 2
NM_001371092.1 NP_001358021.1 ADP-ribosylarginine hydrolase isoform 1
NM_001391992.1 NP_001378921.1 ADP-ribosylarginine hydrolase isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ADP-ribosylarginine hydrolase activity IDA
IDA: 通过直接分析推断
30472116 GOA
enables ADP-ribosylarginine hydrolase activity IMP
IMP: 通过突变表型推断
8349667 GOA
enables magnesium ion binding IDA
IDA: 通过直接分析推断
19407395 GOA
enables potassium ion binding IDA
IDA: 通过直接分析推断
19407395 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein de-ADP-ribosylation IDA
IDA: 通过直接分析推断
30472116 GOA
involved in protein modification process IMP
IMP: 通过突变表型推断
8349667 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ADPRH 蛋白结构

ADP_ribosyl_GH

ADP_ribosyl_GH: ADP-ribosylglycohydrolase (6 - 324)

  • 0
  • 100
  • 200
  • 300
  • 357 a.a.
蛋白主名 其他名称

ADP-ribosylarginine hydrolase

ADP-ribose-L-arginine cleaving enzyme

ADPRH 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ADPRH P54922 SPSB1 Homo sapiens Q96BD6
Y2H Array
32296183
种属内
ADPRH P54922 SPSB1 Homo sapiens Q96BD6
Validated Y2H
32296183
种属内
ADPRH P54922 SPSB1 Homo sapiens Q96BD6
Y2H Prey Pooling
32296183
种属内
ADPRH P54922 TFCP2 Homo sapiens Q12800
Y2H Prey Pooling
25416956
种属内
ADPRH P54922 TFCP2 Homo sapiens Q12800
Validated Y2H
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 ADPRH 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7462 ADPRH/ARH1 Protein, Human (His) P54922 (M1-L357) ≥95%

关联疾病

疾病名称 别名
Tyrosinemia

Hypertyrosinemia

Tyrosinemias

Hereditary Tyrosinemia

Hypertyrosinaemia

Tyrosinaemia

Hereditary Hypertyrosinemia
Glycine N-Methyltransferase Deficiency

GNMT DEFICIENCY

Hypermethioninemia Due To Glycine N-Methyltransferase Deficiency

Hypermethioninemia Due To Gnmt Deficiency

Hypermethioninemia

Hepatic Methionine Adenosyltransferase Deficiency
Mucolipidosis Ii Alpha/Beta

I-Cell Disease

Mucolipidosis Type Ii

Mucolipidosis Ii

Icd

Inclusion Cell Disease

Inclusion-Cell Disease

I Cell Disease

Mucolipidosis 2

MLII

Ml Ii

Ml Ii Alpha/Beta

Gnpta

Leroy Disease

Ml 2

Ml Disorder Type 2

N-Acetylglucosamine 1phosphotransferase Deficiency

Mucolipidosis Type Ii Alpha/Beta

N-Acetylglucosamine 1-Phosphotransferase Deficiency

Deficiency Of N-Acetylglucosamine-1-Phosphotransferase

Mucolipidosis, Type Ii, Alpha/Beta

Ml2

Type Ii Mucolipidosis
Sphingolipidosis

Sphingolipidoses
Arthrogryposis, Renal Dysfunction, And Cholestasis 1

Arc Syndrome

ARCS1

Arthrogryposis Renal Dysfunction Cholestasis Syndrome

Arthrogryposis-Renal Dysfunction-Cholestasis Syndrome

Arcs

Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome

Arthrogryposis, Renal Dysfunction, And Cholestasis

Arthrogryposis-Renal Dysfunction-Cholestasis

Arthrogryposis - Renal Dysfunction - Cholestasis

Arthrogryposis Multiplex Congenita, Renal Dysfunction, And Cholestasis

Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome 1

Arthrogryposis Renal Dysfunction And Cholestasis 1

Arthrogryposis With Renal Dysfunction And Cholestasis Syndrome

Arthrogryposis, Renal Dysfunction, Cholestasis, Type 1

Kidney Failure

Renal Insufficiency
Stuttering

Stammering

Familial Persistent Stuttering

Stuttering, Familial Persistent 1
Leukodystrophy

Leukodystrophies
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00404 ADPRH Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18801 Adprh Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25290 Adprh Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ADPRH RGD RGD:2052
Bos taurus ADPRH VGNC VGNC:25690
Mus musculus ADPRH MGD MGI:1098234
Macaca mulatta ADPRH VGNC VGNC:110386
Canis familiaris ADPRH VGNC VGNC:37670
Others ADPRH NCBI
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