2. Gene
  3. Fech - ferrochelatase Gene

Fech - ferrochelatase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Fcl; fch

基因 ID: 14151 | 基因类型: protein coding

关于 Fech

功能概要

Enables several functions, including ferrochelatase activity; heme binding activity; and iron-responsive element binding activity. Acts upstream of or within several processes, including porphyrin-containing compound metabolic process; regulation of cellular macromolecule biosynthetic process; and very-low-density lipoprotein particle assembly. Located in mitochondrial inner membrane. Is expressed in several structures, including choroid plexus; heart; integumental system; liver and biliary system; and respiratory system. Used to study erythropoietic protoporphyria. Human ortholog(s) of this gene implicated in cutaneous porphyria and erythropoietic protoporphyria. Orthologous to human FECH (ferrochelatase). [provided by Alliance of Genome Resources, Apr 2022]

Fech 基因产物(2)

mRNA Protein Name
NM_001348055.2 NP_001334984.1 ferrochelatase, mitochondrial isoform 2
NM_007998.8 NP_032024.2 ferrochelatase, mitochondrial isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ferrochelatase activity IDA
IDA: 通过直接分析推断
2246229 MGI
enables ferrochelatase activity IMP
IMP: 通过突变表型推断
8325637 MGI
enables heme binding IDA
IDA: 通过直接分析推断
16503645 MGI
enables iron ion binding IDA
IDA: 通过直接分析推断
14981080 MGI
enables iron-responsive element binding IDA
IDA: 通过直接分析推断
7575558 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
20427704 MGI
enables tetrapyrrole binding IDA
IDA: 通过直接分析推断
14981080 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cholesterol metabolic process IMP
IMP: 通过突变表型推断
11160364 MGI
acts upstream of or within detection of UV IMP
IMP: 通过突变表型推断
12149233 MGI
acts upstream of or within erythrocyte differentiation IMP
IMP: 通过突变表型推断
1939658 MGI
involved in heme A biosynthetic process IMP
IMP: 通过突变表型推断
15677551 MGI
involved in heme B biosynthetic process IMP
IMP: 通过突变表型推断
15677551 MGI
involved in heme O biosynthetic process IMP
IMP: 通过突变表型推断
15677551 MGI
acts upstream of or within heme biosynthetic process IDA
IDA: 通过直接分析推断
15496139 MGI
acts upstream of or within heme biosynthetic process IMP
IMP: 通过突变表型推断
8611576 MGI
acts upstream of or within multicellular organismal-level iron ion homeostasis IMP
IMP: 通过突变表型推断
17003376 MGI
acts upstream of or within porphyrin-containing compound biosynthetic process IMP
IMP: 通过突变表型推断
12149233 MGI
acts upstream of or within protoporphyrinogen IX metabolic process IGI
IGI: 通过遗传相互作用推断
15931390 MGI
acts upstream of or within regulation of eIF2 alpha phosphorylation by heme IGI
IGI: 通过遗传相互作用推断
15931390 MGI
acts upstream of or within regulation of eIF2 alpha phosphorylation by heme IMP
IMP: 通过突变表型推断
15931390 MGI
acts upstream of or within regulation of hemoglobin biosynthetic process IGI
IGI: 通过遗传相互作用推断
15931390 MGI
acts upstream of or within response to light stimulus IMP
IMP: 通过突变表型推断
1939658 MGI
acts upstream of or within very-low-density lipoprotein particle assembly IMP
IMP: 通过突变表型推断
11160364 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrial inner membrane IDA
IDA: 通过直接分析推断
27599036 MGI
is active in mitochondrial matrix IDA
IDA: 通过直接分析推断
30366982 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

ferrochelatase, mitochondrial

heme synthase

heme synthetase

protoheme ferro-lyase

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-114758 Pyridoxal isonicotinoyl hydrazone Inhibitor 99.96% 否
HY-RS04857 FECH Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20276 Fech Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26784 Fech Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Fech NCBI NCBI:2235
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