2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Derazantinib dihydrochloride

Derazantinib dihydrochloride  (Synonyms: ARQ-087 dihydrochloride)

目录号: HY-19981B
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摩尔计算器

Derazantinib (ARQ-087) dihydrochloride 是一种 ATP 竞争性、口服活性 FGFR 抑制剂 (IC50s: FGFR2 为 1.8 nM，FGFR1 和 3 为 4.5 nM)。Derazantinib dihydrochloride 抑制 FGFR 磷酸化。Derazantinib dihydrochloride 抑制多种异种移植模型中的肿瘤生长。

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Derazantinib dihydrochloride Chemical Structure

Derazantinib dihydrochloride Chemical Structure

CAS No. : 1821329-75-2

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Derazantinib dihydrochloride 的其他形式现货产品:

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Derazantinib dihydrochloride 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Derazantinib (ARQ-087) dihydrochloride is an ATP competitive and orally activeFGFR inhibitor (IC50s: 1.8 nM for FGFR2, 4.5 nM for FGFR1 and 3). Derazantinib dihydrochloride inhibits FGFR phosphorylation. Derazantinib dihydrochloride inhibits tumor growth in multiple xenograft models[1][2].

IC50 & Target

1.8 nM for FGFR2, 4.5 nM for FGFR1 and 3 nM[1]
分子量

541.49

Formula

C29H31Cl2FN4O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Derazantinib dihydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Derazantinib1821329-75-2ARQ-087ARQ087ARQ 087EGFREpidermal growth factor receptorErbB-1HER1iCCAtumorSNU-16NCI-H716Inhibitorinhibitorinhibit

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