2. Gene
  3. Fosl2 - fos-like antigen 2 Gene

Fosl2 - fos-like antigen 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Fra-2

基因 ID: 14284 | 基因类型: protein coding

关于 Fosl2

功能概要

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and chromatin binding activity. Involved in positive regulation of transcription, DNA-templated. Acts upstream of or within keratinocyte development; positive regulation of fibroblast proliferation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; skeleton; skin; and telencephalon. Used to study idiopathic pulmonary fibrosis and systemic scleroderma. Orthologous to human FOSL2 (FOS like 2, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Apr 2022]

Fosl2 基因产物(1)

mRNA Protein Name
NM_008037.4 NP_032063.2 fos-related antigen 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
24464219 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
19289495 MGI
enables chromatin binding IDA
IDA: 通过直接分析推断
25547114 MGI
enables transcription cis-regulatory region binding IDA
IDA: 通过直接分析推断
22326952 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within B cell differentiation IMP
IMP: 通过突变表型推断
28566276 MGI
acts upstream of or within B cell proliferation IMP
IMP: 通过突变表型推断
28566276 MGI
acts upstream of or within NK T cell differentiation IMP
IMP: 通过突变表型推断
19620306 MGI
acts upstream of or within T cell differentiation IDA
IDA: 通过直接分析推断
32610127 MGI
acts upstream of or within T cell receptor signaling pathway IDA
IDA: 通过直接分析推断
32610127 MGI
acts upstream of or within T cell receptor signaling pathway IMP
IMP: 通过突变表型推断
32610127 MGI
acts upstream of or within T-helper 2 cell cytokine production IDA
IDA: 通过直接分析推断
30233597 MGI
acts upstream of or within alveolar secondary septum development IMP
IMP: 通过突变表型推断
28818870 MGI
acts upstream of or within bone development IDA
IDA: 通过直接分析推断
24046454 MGI
acts upstream of or within bone development IMP
IMP: 通过突变表型推断
24046454 MGI
acts upstream of or within bone mineralization IMP
IMP: 通过突变表型推断
15509771 MGI
acts upstream of or within cartilage development IMP
IMP: 通过突变表型推断
15509771 MGI
acts upstream of or within cell morphogenesis IMP
IMP: 通过突变表型推断
18548006 MGI
acts upstream of or within chemokine (C-C motif) ligand 11 production IDA
IDA: 通过直接分析推断
30233597 MGI
acts upstream of or within chemokine production IDA
IDA: 通过直接分析推断
33655757 MGI
acts upstream of or within chondrocyte differentiation IMP
IMP: 通过突变表型推断
15509771 MGI
acts upstream of or within chondrocyte proliferation IMP
IMP: 通过突变表型推断
15509771 MGI
acts upstream of or within collagen biosynthetic process IMP
IMP: 通过突变表型推断
20837772 MGI
acts upstream of or within collagen metabolic process IDA
IDA: 通过直接分析推断
30233597 MGI
acts upstream of or within cytokine production IDA
IDA: 通过直接分析推断
33655757 MGI
acts upstream of or within cytokine production IMP
IMP: 通过突变表型推断
30181393 MGI
acts upstream of or within fat cell apoptotic process IMP
IMP: 通过突变表型推断
24464219 MGI
acts upstream of or within fat cell differentiation IMP
IMP: 通过突变表型推断
24464219 MGI
acts upstream of or within fat pad development IMP
IMP: 通过突变表型推断
24464219 MGI
acts upstream of or within gene expression IDA
IDA: 通过直接分析推断
22326952 MGI
acts upstream of or within gene expression IMP
IMP: 通过突变表型推断
18548006 MGI
acts upstream of or within glucose homeostasis IDA
IDA: 通过直接分析推断
24046454 MGI
acts upstream of or within granulocyte macrophage colony-stimulating factor production IMP
IMP: 通过突变表型推断
30181393 MGI
acts upstream of or within growth plate cartilage development IMP
IMP: 通过突变表型推断
15509771 MGI
acts upstream of or within homeostasis of number of cells IMP
IMP: 通过突变表型推断
19620306 MGI
acts upstream of or within homeostasis of number of cells within a tissue IDA
IDA: 通过直接分析推断
33655757 MGI
acts upstream of or within homeostasis of number of cells within a tissue IMP
IMP: 通过突变表型推断
24464219 MGI
acts upstream of or within inflammatory response IDA
IDA: 通过直接分析推断
30233597 MGI
acts upstream of or within inflammatory response IMP
IMP: 通过突变表型推断
32610127 MGI
acts upstream of or within inflammatory response to antigenic stimulus IMP
IMP: 通过突变表型推断
19620306 MGI
acts upstream of or within innate immune response IMP
IMP: 通过突变表型推断
30181393 MGI
acts upstream of or within insulin metabolic process IDA
IDA: 通过直接分析推断
24046454 MGI
acts upstream of or within interleukin-2 production IMP
IMP: 通过突变表型推断
19620306 MGI
acts upstream of or within interleukin-4 production IMP
IMP: 通过突变表型推断
19620306 MGI
acts upstream of or within keratinocyte development IMP
IMP: 通过突变表型推断
25547114 MGI
acts upstream of or within lung alveolus development IMP
IMP: 通过突变表型推断
28818870 MGI
acts upstream of or within lung connective tissue development IMP
IMP: 通过突变表型推断
31135379 MGI
acts upstream of or within lung development IMP
IMP: 通过突变表型推断
30181393 MGI
acts upstream of or within macrophage differentiation IDA
IDA: 通过直接分析推断
31135379 MGI
acts upstream of or within macrophage differentiation IMP
IMP: 通过突变表型推断
30181393 MGI
acts upstream of or within mucus secretion IDA
IDA: 通过直接分析推断
30233597 MGI
acts upstream of or within multicellular organism growth IMP
IMP: 通过突变表型推断
15509771 MGI
acts upstream of or within myofibroblast differentiation IMP
IMP: 通过突变表型推断
28818870 MGI
acts upstream of or within neutrophil differentiation IMP
IMP: 通过突变表型推断
30181393 MGI
acts upstream of or within ossification IMP
IMP: 通过突变表型推断
20837772 MGI
acts upstream of or within osteoblast differentiation IMP
IMP: 通过突变表型推断
20837772 MGI
acts upstream of or within osteoclast differentiation IMP
IMP: 通过突变表型推断
18548006 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
22585681 MGI
acts upstream of or within positive regulation of fibroblast proliferation IDA
IDA: 通过直接分析推断
7936655 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
25547114 MGI
acts upstream of or within regulation of multicellular organism growth IDA
IDA: 通过直接分析推断
24046454 MGI
acts upstream of or within regulation of multicellular organism growth IMP
IMP: 通过突变表型推断
24046454 MGI
acts upstream of or within regulation of myofibroblast differentiation IDA
IDA: 通过直接分析推断
31135379 MGI
acts upstream of or within regulation of myofibroblast differentiation IMP
IMP: 通过突变表型推断
31135379 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
28566276 MGI
acts upstream of or within response to Gram-positive bacterium IDA
IDA: 通过直接分析推断
33655757 MGI
acts upstream of or within response to bleomycin IDA
IDA: 通过直接分析推断
31135379 MGI
acts upstream of or within response to glucocorticoid IDA
IDA: 通过直接分析推断
30233597 MGI
acts upstream of or within response to hypoxia IMP
IMP: 通过突变表型推断
18548006 MGI
acts upstream of or within response to interleukin-13 IDA
IDA: 通过直接分析推断
30233597 MGI
acts upstream of or within response to interleukin-7 IMP
IMP: 通过突变表型推断
28566276 MGI
acts upstream of or within response to leukemia inhibitory factor IMP
IMP: 通过突变表型推断
18548006 MGI
acts upstream of or within response to lipopolysaccharide IMP
IMP: 通过突变表型推断
30181393 MGI
acts upstream of or within response to xenobiotic stimulus IDA
IDA: 通过直接分析推断
30233597 MGI
acts upstream of or within smooth muscle tissue development IDA
IDA: 通过直接分析推断
30233597 MGI
acts upstream of or within tissue remodeling IDA
IDA: 通过直接分析推断
30233597 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
25547114 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

fos-related antigen 2

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS18065 Fosl2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS05035 FOSL2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24540 Fosl2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Fosl2 NCBI NCBI:2355
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