2. Gene
  3. Gabra2 - gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2 Gene

Gabra2 - gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Gabra-2; C630048P16Rik

基因 ID: 14395 | 基因类型: protein coding

关于 Gabra2

功能概要

Predicted to enable GABA-gated chloride ion channel activity; inhibitory extracellular ligand-gated ion channel activity; and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to contribute to GABA-A receptor activity; benzodiazepine receptor activity; and Chloride Channel activity. Involved in inhibitory synapse assembly. Located in several cellular components, including dendrite; inhibitory synapse; and neuronal cell body. Is integral component of postsynaptic specialization membrane. Is active in GABA-ergic synapse. Is expressed in brain and lens. Human ortholog(s) of this gene implicated in alcohol use disorder; autistic disorder; and developmental and epileptic encephalopathy 78. Orthologous to human GABRA2 (gamma-aminobutyric acid type A receptor subunit alpha2). [provided by Alliance of Genome Resources, Apr 2022]

Gabra2 基因产物(1)

mRNA Protein Name
NM_008066.4 NP_032092.1 gamma-aminobutyric acid receptor subunit alpha-2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
28978485 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in inhibitory synapse assembly IDA
IDA: 通过直接分析推断
27129275 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in GABA-ergic synapse IDA
IDA: 通过直接分析推断
14627650 MGI
located in axon IDA
IDA: 通过直接分析推断
9682826 MGI
located in dendrite IDA
IDA: 通过直接分析推断
24554721 MGI
located in inhibitory synapse IDA
IDA: 通过直接分析推断
24554721 MGI
located in neuronal cell body IDA
IDA: 通过直接分析推断
24554721 MGI
located in postsynapse IDA
IDA: 通过直接分析推断
24554721 MGI
is active in postsynaptic specialization membrane IDA
IDA: 通过直接分析推断
14627650 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

gamma-aminobutyric acid receptor subunit alpha-2

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05210 GABRA2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20551 Gabra2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27060 Gabra2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Gabra2 NCBI NCBI:2555
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