CSN2 - casein beta Gene

中文名称：酪蛋白β

种属: Homo sapiens

同用名: CASB; PDC213

基因 ID: 1447 | 基因类型: protein coding

关于 CSN2

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:69,955,256-69,965,728 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele and 86 orthologues. Low expression observed in reference dataset.

功能概要

该基因是 β 酪蛋白家族的成员。酪蛋白有两种类型，β (由该基因编码) 和 kappa，两者均分泌于人乳中。 β 酪蛋白是人乳中的主要蛋白质，也是哺乳婴儿必需氨基酸的主要来源。 β 和 kappa 酪蛋白一起作用形成球形胶束，这些胶束在其中结合重要的膳食矿物质，例如钙和磷。此外，该蛋白的 C 端 14 个氨基酸具有抗菌活性，尤其是在早产乳中，对金黄色葡萄球菌和小肠结肠炎耶氏菌具有抗菌活性。可变剪接导致多个转录本变体。[RefSeq 提供，2020 年 7 月]

This gene is a member of the beta casein family. There are two types of casein protein, beta (encoded by this gene) and kappa, both of which are secreted in human milk. Beta casein is the principal protein in human milk and the primary source of essential Amino acids for a suckling infant. Beta and kappa casein proteins acting together form spherical micelles which bind within them important dietary Minerals, such as calcium and phosphorous. In addition, the C-terminal 14 aa of the protein has antimicrobial activity, especially in preterm milk, displaying Antibacterial activity against S. aureus and Y. enterocolitica. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2020]

CSN2 基因产物(3)

mRNA	Protein	Name
NM_001302770.2	NP_001289699.1	beta-casein isoform 2 precursor
NM_001385731.1	NP_001372660.1	beta-casein isoform 3 precursor
NM_001891.4	NP_001882.1	beta-casein isoform 1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cysteine-type endopeptidase inhibitor activity	IDA IDA: 通过直接分析推断	12788072	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	31515488	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in lactation	IDA IDA: 通过直接分析推断	7979373	GOA
involved in negative regulation of cysteine-type endopeptidase activity	IDA IDA: 通过直接分析推断	12788072	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in extracellular space	IDA IDA: 通过直接分析推断	7979373	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CSN2 蛋白结构

Casein

0
100
200
226 a.a.

蛋白主名

其他名称

beta-casein

CSN2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CSN2	P05814	FHL2	Homo sapiens	Q14192	Validated Y2H	32296183
种属内	CSN2	P05814	FHL2	Homo sapiens	Q14192	Y2H Array	32296183
种属内	CSN2	P05814	FHL2	Homo sapiens	Q14192	Y2H Array	31515488
种属内	CSN2	P05814	FHL2	Homo sapiens	Q14192	Y2H Prey Pooling	32296183
种属内	CSN2	P05814	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
种属内	CSN2	P05814	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
种属内	CSN2	P05814	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

CSN2 抗体

目录号	产品名	应用	反应物种
HY-P81091	Beta casein Antibody (YA3483)	WB, IP	Human

关联疾病

疾病名称

别名

Milk Allergy

Milk Allergic Reaction	Milk Hypersensitivity
Allergy Milk

Mastitis

Breast Inflammation	Inflammatory Breast Disease
Inflammatory Disease Of Breast	Inflammation Of Non-Human Mammary Gland
Inflammatory Disorder Of Breast	Mastitis Nos
Acute Mastitis Nos	Acute Nonpuerperal Mastitis
Nonpuerperal Mastitis Nos	Subacute Mastitis Nos

Goat Milk Allergy

Capra Hircus Milk Allergy

Cow Milk Allergy

Bos Taurus Milk Allergy

Cow'S Milk Protein Sensitivity

Type 1 Diabetes Mellitus

Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus Type 1
IDDM	Type 1 Diabetes
Insulin-Dependent Diabetes Mellitus	T1D
Juvenile-Onset Diabetes	Jod
Diabetes Mellitus, Type 1	Diabetes Mellitus, Insulin-Dependent-1
Type I Diabetes Mellitus	Autoimmune Diabetes
Juvenile Diabetes	Juvenile-Onset Diabetes Mellitus
Diabetes, Insulin Dependent	Insulin-Dependent Diabetes Mellitus-1
Diabetes Mellitus Insulin-Dependent	Diabetes Autoimmune
Diabetes Mellitus, Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 1, Susceptibility To
Diabetes Type 1	Type I Diabetes
Diabetes, Autoimmune	T1dm - [Type 1 Diabetes Mellitus]
Iddm - [Insulin Dependent Diabetes Mellitus]	Type 1 Iddm
Juvenile Diabetes Mellitus Without Compications	Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications
Juvenile-Onset Diabetes Mellitus Without Compications	Ketosis-Prone Diabetes Mellitus Without Compications
Juvenile-Onset-Type Diabetes Mellitus Without Compications

Lactose Intolerance

Lactose Malabsorption	Lm - Lactose Malabsorption
Alactasia	Dairy Product Intolerance
Hypolactasia	Milk Sugar Intolerance
Cow Milk Enteropathy	Intolerance Or Malabsorption Of Lactose
Lm - [Lactose Malabsorption]	Milk Intolerance

Epilepsy, Juvenile Absence 1

Epilepsy, Juvenile Absence, Susceptibility To, 1	EJA1
JAE1	Juvenile Absence Epilepsy 1
Susceptibility To Juvenile Absence Epilepsy 1	Epilepsy, Juvenile Absence, Susceptibility To, Type 1
Absence Epilepsy

Polyposis Syndrome, Hereditary Mixed, 2

HMPS2	Hereditary Mixed Polyposis Syndrome 2
Polyposis Syndrome, Mixed Hereditary 2	Polyposis Syndrome, Hereditary Mixed, Type 2

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03027	COPS2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS03243	CSN2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	CSN2	RGD	RGD:61981
Mus musculus	CSN2	MGD	MGI:88541
Felis catus	CSN2	VGNC	VGNC:78476
Macaca mulatta	CSN2	VGNC	VGNC:71523
Canis familiaris	CSN2	VGNC	VGNC:39665
Bos taurus	CSN2	VGNC	VGNC:27764

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CSN2 - casein beta Gene

关于 CSN2

功能概要

CSN2 基因产物(3)

CSN2 蛋白结构

CSN2 蛋白互作信息

CSN2 抗体

关联疾病

直系同源

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CSN2 - casein beta Gene

关于 CSN2

功能概要

CSN2 基因产物(3)

CSN2 蛋白结构

CSN2 蛋白互作信息

CSN2 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z