2. Gene
  3. LRFN5 - leucine rich repeat and fibronectin type III domain containing 5 Gene

LRFN5 - leucine rich repeat and fibronectin type III domain containing 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含富亮氨酸的重复序列和纤连蛋白 III 型结构域， 5

种属: Homo sapiens

同用名: SALM5; FIGLER8; C14orf146

基因 ID: 145581 | 基因类型: protein coding

关于 LRFN5

Cytogenetic location: 14q21.1 Genomic coordinates (GRCh38): 14:41,606,876-41,904,549 (from NCBI)

This gene has 5 transcripts (splice variants), 207 orthologues and 25 paralogues. Biased expression in brain (RPKM 2.4), adrenal (RPKM 0.8) and 13 other tissues.

功能概要

该基因编码的蛋白质属于富含亮氨酸的重复序列和含有纤连蛋白 III 型结构域的蛋白质家族。小鼠中的一种类似蛋白质，一种糖基化的跨膜蛋白，被认为在突触前分化中起作用。[RefSeq 提供，2016 年 9 月]

This gene encodes a protein that belongs to the leucine-rich repeat and fibronectin type III domain-containing family of proteins. A similar protein in mouse, a glycosylated transmembrane protein, is thought to function in presynaptic differentiation. [provided by RefSeq, Sep 2016]

LRFN5 基因产物(4)

mRNA Protein Name
NM_001330106.2 NP_001317035.1 leucine-rich repeat and fibronectin type-III domain-containing protein 5 isoform 2 precursor
NM_001346173.2 NP_001333102.1 leucine-rich repeat and fibronectin type-III domain-containing protein 5 isoform 1 precursor
NM_001346175.2 NP_001333104.1 leucine-rich repeat and fibronectin type-III domain-containing protein 5 isoform 2 precursor
NM_152447.5 NP_689660.2 leucine-rich repeat and fibronectin type-III domain-containing protein 5 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
27152329 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of inflammatory response IDA
IDA: 通过直接分析推断
27152329 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LRFN5 蛋白结构

LRR_5

LRR_5: Leucine rich repeats (6 copies) (64 - 194)

I-set

I-set: Immunoglobulin I-set domain (288 - 374)

  • 0
  • 200
  • 400
  • 600
  • 719 a.a.
蛋白主名 其他名称

leucine-rich repeat and fibronectin type-III domain-containing protein 5

fibronectin type III, immunoglobulin and leucine rich repeat domains 8

关联疾病

疾病名称 别名
Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07783 LRFN5 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21633 Lrfn5 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28151 Lrfn5 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris LRFN5 VGNC VGNC:42764
Macaca mulatta LRFN5 VGNC VGNC:74318
Mus musculus LRFN5 MGD MGI:2144814
Bos taurus LRFN5 VGNC VGNC:30979
Rattus norvegicus LRFN5 RGD RGD:1309357
Felis catus LRFN5 VGNC VGNC:63278
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