2. Gene
  3. Nr4a1 - nuclear receptor subfamily 4, group A, member 1 Gene

Nr4a1 - nuclear receptor subfamily 4, group A, member 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Hmr; N10; TR3; Gfrp; Hbr1; NP10; TIS1; GFRP1; Hbr-1; NGFIB; nur77; NGFI-B; NUR77-1; NUR77-2

基因 ID: 15370 | 基因类型: protein coding

关于 Nr4a1

功能概要

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; identical protein binding activity; and sequence-specific DNA binding activity. Involved in cellular response to corticotropin-releasing hormone stimulus; fat cell differentiation; and negative regulation of cell cycle. Acts upstream of or within several processes, including positive regulation of transcription by RNA polymerase II; regulation of apoptotic process; and skeletal muscle cell differentiation. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including bone; genitourinary system; hemolymphoid system; nervous system; and submandibular gland primordium. Orthologous to human NR4A1 (nuclear receptor subfamily 4 group A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Nr4a1 基因产物(6)

mRNA Protein Name
NM_001411253.1 NP_001398182.1 nuclear receptor subfamily 4 group A member 1
NM_001411254.1 NP_001398183.1 nuclear receptor subfamily 4 group A member 1
NM_010444.3 NP_034574.1 nuclear receptor subfamily 4 group A member 1
NM_001411253.1 NP_001398182.1 nuclear receptor subfamily 4 group A member 1
NM_001411254.1 NP_001398183.1 nuclear receptor subfamily 4 group A member 1
NM_010444.3 NP_034574.1 nuclear receptor subfamily 4 group A member 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
18292087 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
9155013 MGI
enables double-stranded DNA binding IDA
IDA: 通过直接分析推断
37001519 MGI
enables identical protein binding IPI
IPI: 通过物理相互作用推断
18388149 MGI
enables lipopolysaccharide binding IDA
IDA: 通过直接分析推断
37001519 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
8961274 MGI
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
8961274 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within apoptotic process IMP
IMP: 通过突变表型推断
17434920 MGI
involved in cellular response to corticotropin-releasing hormone stimulus IDA
IDA: 通过直接分析推断
10523643 MGI
involved in detection of lipopolysaccharide IDA
IDA: 通过直接分析推断
37001519 MGI
involved in fat cell differentiation IDA
IDA: 通过直接分析推断
18945812 MGI
involved in negative regulation of cell cycle IDA
IDA: 通过直接分析推断
18945812 MGI
acts upstream of or within negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: 通过直接分析推断
12815108 MGI
involved in non-canonical inflammasome complex assembly IMP
IMP: 通过突变表型推断
37001519 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
8961274 MGI
acts upstream of or within positive regulation of apoptotic process IDA
IDA: 通过直接分析推断
14657025 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
8961274 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
15155786 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
28775000 MGI
acts upstream of or within skeletal muscle cell differentiation IMP
IMP: 通过突变表型推断
22147266 MGI
acts upstream of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
15155786 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
30134173 MGI
located in cytosol IDA
IDA: 通过直接分析推断
37001519 MGI
located in nucleus IDA
IDA: 通过直接分析推断
12815108 MGI
part of transcription regulator complex IDA
IDA: 通过直接分析推断
9155013 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

nuclear receptor subfamily 4 group A member 1

hormone receptor

nuclear hormone receptor NUR/77

nuclear protein N10

orphan nuclear receptor HMR

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-P1624 Teduglutide Activator 99.94% 否
HY-P1624A Teduglutide TFA Activator / 否
Pre-clinical Phase
生物活性分子 (8)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N2148 Cytosporone B Agonist 99.23% 否
HY-112055 DIM-C-pPhOH 99.05% 否
HY-112056 DIM-C-pPhCO2Me 99.47% 否
HY-159779 NR-V04 Degrader 96.71% 否
HY-160498 Amoitone B Agonist 98.50% 否
HY-RS09550 NR4A1 Human Pre-designed siRNA Set A / 否
HY-RS16573 Nr4a1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23006 Nr4a1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nr4a1 NCBI NCBI:3164
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