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  2. Ifnar1 - interferon (alpha and beta) receptor 1 Gene

Ifnar1 - interferon (alpha and beta) receptor 1 Gene

中文名称:干扰素 (α 和 β) 受体 1

种属: Mus musculus

同用名: Ifar; Ifrc; Ifnar; Infar

基因 ID: 15975 | 基因类型: protein coding

关于 Ifnar1

Chromosome 16: 91,282,126-91,304,329 forward strand.GRCm39:CM001009.3

This gene has 8 transcripts (splice variants), 226 orthologues, 11 paralogues and is associated with 69 phenotypes. Ubiquitous expression in limb E14.5 (RPKM 8.7), CNS E18 (RPKM 8.4) and 28 other tissues.

功能概要

该基因编码的蛋白可启动 I 型干扰素结合活性和 I 型干扰素受体活性。参与细胞对细胞因子刺激的反应;大分子代谢过程的正向调控;和对脂多糖的反应。作用于多个过程的上游或内部,包括对病毒的防御反应;细胞因子产生的正调节;和调节肽基酪氨酸磷酸化。是质膜的组成部分。以多种结构表达,包括消化系统;中枢神经系统;泌尿生殖系统;外皮系统;和感觉器官。该基因的人类直系同源物与丙型肝炎有关。与人类 IFNAR1(干扰素 α 和 β 受体亚基 1)直系同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables type I interferon binding activity and type I interferon receptor activity. Involved in cellular response to cytokine stimulus; positive regulation of macromolecule metabolic process; and response to lipopolysaccharide. Acts upstream of or within several processes, including defense response to virus; positive regulation of cytokine production; and regulation of peptidyl-tyrosine phosphorylation. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in hepatitis C. Orthologous to human IFNAR1 (interferon alpha and beta receptor subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Ifnar1 基因产物(1)

mRNA Protein Name
NM_010508.2 NP_034638.2 interferon alpha/beta receptor 1 precursor

Ifnar1 蛋白结构

FN3

FN3: cl21522 (18 - 113)

Interfer-bind

Interfer-bind: pfam09294 (125 - 223)

FN3

FN3: cl21522 (220 - 318)

FN3

FN3: cl21522 (334 - 421)

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  • 590 a.a.
蛋白主名 其他名称

interferon alpha/beta receptor 1

IFN-R-1

IFN-alpha/beta receptor 1

IFN-alpha/betaR

INF-a receptor

type I interferon receptor 1

重组 Ifnar1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73127 IFNAR1 Protein, Mouse (HEK293, His) P33896/NP_034638.2(E27-T429) ≥95%
HY-P78308 IFNAR1 Protein, Mouse (HEK293, Fc) P33896 (E27-T429) ≥95%
HY-P78309 IFNAR1 Protein, Mouse (HEK293, His-Avi) P33896 (E27-T429) ≥95%

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ifnar1 NCBI NCBI:3454
Macaca mulatta Ifnar1 NCBI NCBI:699604