DCT - dopachrome tautomerase Gene

中文名称：多巴色素互变异构酶

种属: Homo sapiens

同用名: OCA8; TRP-2; TYRP2

基因 ID: 1638 | 基因类型: protein coding

关于 DCT

Cytogenetic location: 13q32.1 Genomic coordinates (GRCh38): 13:94,436,811-94,549,406 (from NCBI)

This gene has 5 transcripts (splice variants), 210 orthologues, 2 paralogues and is associated with 2 phenotypes. Restricted expression toward skin (RPKM 44.8).

功能概要

预测可启用多巴色素异构酶活性。参与对蓝光的反应。位于细胞内膜结合的细胞器和质膜中。与眼皮肤白化病有关。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable dopachrome isomerase activity. Involved in response to blue LIGHT. Located in intracellular membrane-bounded organelle and plasma membrane. Implicated in oculocutaneous albinism. [provided by Alliance of Genome Resources, Apr 2022]

DCT 基因产物(7)

mRNA	Protein	Name
NM_001129889.3	NP_001123361.1	L-dopachrome tautomerase isoform 2 precursor
NM_001322182.2	NP_001309111.1	L-dopachrome tautomerase isoform 3
NM_001322183.2	NP_001309112.1	L-dopachrome tautomerase isoform 3
NM_001322184.2	NP_001309113.1	L-dopachrome tautomerase isoform 3
NM_001322185.2	NP_001309114.1	L-dopachrome tautomerase isoform 3
NM_001322186.2	NP_001309115.1	L-dopachrome tautomerase isoform 4
NM_001922.5	NP_001913.2	L-dopachrome tautomerase isoform 1 precursor

DCT 蛋白结构

Tyrosinase

0
100
200
300
400
519 a.a.

蛋白主名

其他名称

L-dopachrome tautomerase

重组 DCT 蛋白

目录号	产品名	蛋白编号	纯度
HY-P72168	DCT Protein, Human (His-SUMO)	P40126 (Q24-T472)	≥95%

关联疾病

疾病名称

别名

Oculocutaneous Albinism, Type Viii

OCA8	Oculocutaneous Albinism Type 8
Albinism, Oculocutaneous, 8

Albinism

Amelanotic Melanoma

Melanoma, Amelanotic	Melanoma Amelanotic
Amelanotic Skin Melanoma

Oculocutaneous Albinism

Albinism, Oculocutaneous	Oca
Albinism Oculocutaneous	Oca - [Oculocutaneous Albinism]

Vitiligo-Associated Multiple Autoimmune Disease Susceptibility 1

Vitiligo	VAMAS1
Slev1	Vtlg
Systemic Lupus Erythematosus, Vitiligo-Related	Vitiligo-Associated Multiple Autoimmune Disease 1
Systemic Lupus Erythematosus Vitiligo-Related

Chediak-Higashi Syndrome

CHS	Chédiak-Higashi Syndrome
Chediak - Steinbrinck Anomaly	Chediak Higashi Syndrome
Chediak-Steinbrinck-Higashi Syndrome	Oculocutaneous Albinism With Leukocyte Defect
Chediak-Higashi Disease	Chediak-Higashi-Steinbrink Syndrome

Microphthalmia

Microphthalmos	Isolated Anophthalmia-Microphthalmia Syndrome
Isolated Microphthalmia-Anophthalmia-Coloboma	Simple Microphthalmos
Clinical Anophthalmia	Isolated Anophthalmia - Microphthalmia
Isolated Pure Microphthalmia	Mac Spectrum
Microphthalmia-Anophthalmia-Coloboma Spectrum	Primitive Anophthalmia
Globe Of Eye Small	Small Eyeball
Hypoplasia Of Eye	Isolated Nanophthalmos
Rudimentary Eye	Dysplasia Of Eye

Albinism, Oculocutaneous, Type Iv

OCA4	Oculocutaneous Albinism Type 4
Oculocutaneous Albinism, Type Iv	Oculocutaneous Albinism Type Iv
Albinism, Oculocutaneous, 4

Hermansky-Pudlak Syndrome

Hps	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells
Hermanski-Pudlak Syndrome	Hermansky Pudlak Syndrome
Platelet Storage Pool Deficiency

Albinism, Oculocutaneous, Type Iii

Rufous Oculocutaneous Albinism	Oculocutaneous Albinism Type 3
OCA3	Roca
Xanthism	Oculocutaneous Albinism Type Iii
Albinism Iii	Oculocutaneous Albinism, Type Iii
Albinism 3	Albinism, Oculocutaneous, Type 3
Rufous Oca	Red Oculocutaneous Albinism
Xanthous Oculocutaneous Albinism	Albinism, Oculocutaneous, 3
Oca-Iii

Albinism, Oculocutaneous, Type Ib

OCA1B	Oculocutaneous Albinism Type 1b
Albinism, Yellow Mutant Type	Yellow Albinism
Oculocutaneous Albinism Type Ib	Temperature-Sensitive Oculocutaneous Albinism Type 1
Oculocutaneous Albinism, Type Ib	Yellow Mutant Albinism
Oca1-Ts	Ts Oca Type 1
Oculocutaneous Albinism, Amish Type	Platinum Oculocutaneous Albinism
Yellow Oculocutaneous Albinism	Albinism, Oculocutaneous, 1b
Albinism Yellow Mutant Type	Oca-Ib
Oca-Its	Oculocutaneous Albinism Type I Temperature-Sensitive
Albinism, Oculocutaneous, Type I, Temperature-Sensitive	Minimal Pigment Oculocutaneous Albinism

Tietz Albinism-Deafness Syndrome

Tietz Syndrome	Albinism-Deafness Of Tietz
Hypopigmentation/Deafness Of Tietz	Tietze'S Syndrome
TADS	Costochondral Junction Syndrome
Costochondritis	Tietze Syndrome
Hypopigmentation-Deafness Syndrome	Costalchondritis
Slipping Rib Syndrome	Tietze'S Disease
Chondropathia Tuberosa	Albinism And Complete Nerve Deafness
Tietz'S Syndrome	Hypopigmentation-Hearing Loss Syndrome
Costal Chondritis	Abnormality Of The Costochondral Junction

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Waardenburg'S Syndrome

Waardenburg Syndrome	Van Der Hoeve Halbertsma Waardenburg Gualdi Syndrome
Van Der Hoeve Halbertsona Waardenburg Syndrome	Waardenburg Shah Syndrome
Waardenburg, Types I And/Or Ii	Mende Syndrome
Waardenburgs Syndrome	Waardenburg Syndrome, Type 4a

Waardenburg Syndrome, Type 2a

Waardenburg Syndrome Type 2a	WS2A
Waardenburg Syndrome, Type Iia	Waardenburg Syndrome Without Dystopia Canthorum
Ws2	Waardenburg Syndrome Type Iia
Waardenburg Syndrome 2a

Piebald Trait

Piebaldism	PBT
Partial Albinism	Albinoidism, Oculocutaneous, Autosomal Dominant

Acute Contagious Conjunctivitis

Pink Eye	Contagious Opthalmia
Pinkeye	Conjunctivitis
Keratoconjunctivitis Due To Mycoplasma Conjunctivae

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Melanoma, Cutaneous Malignant 1

Familial Melanoma	Melanoma, Cutaneous Malignant, Susceptibility To, 1
Melanoma, Malignant	CMM1
Melanoma, Cutaneous Malignant	Cmm
Familial Atypical Mole-Malignant Melanoma Syndrome	Fammm
Melanoma, Familial	Mlm
Dysplastic Nevus Syndrome, Hereditary	Dns
B-K Mole Syndrome	Melanoma, Cutaneous Malignant, 1
Malignant Melanoma, Cutaneous	Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1
Dysplastic Nevus Syndrome	Cutaneous Melanoma
Familial Atypical Mole Melanoma Syndrome	Hereditary Melanoma

Melanoma, Uveal

Uveal Melanoma	Choroidal Melanoma
Melanoma Of Uvea	Iris Melanoma
Malignant Melanoma Of Choroid	Malignant Melanoma Of Iris

Hirschsprung Disease 1

Hirschsprung Disease	Aganglionic Megacolon
Hscr	Hirschsprung'S Disease
Congenital Megacolon	Congenital Intestinal Aganglionosis
Colonic Aganglionosis	Hirschsprung Disease, Susceptibility To, 1
Hirschsprung Disease, Protection Against	HSCR1
Mgc	Pelvirectal Achalasia
Total Intestinal Aganglionosis	Megacolon, Aganglionic
Macrocolon	Hscr 1
Hirschsprung Disease Type 1	Hirschsprung Disease, Type 1
Congenital Dilatation Of Colon	Aganglionosis
Congenital Aganglionic Megacolon	Aganglionosis Of Colon
Bowel Aganglionosis	Colon Aganglionosis
Hirschsprung Megacolon

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	是否罕见病
HY-113042	Prostaglandin B2		≥99.0%	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-138561A	EFdA-TP tetraammonium	Inhibitor	98.03%	否
HY-138561B	EFdA-TP tetrasodium	Inhibitor	95.18%	否
HY-138561C	EFdA-TP tetralithium	Inhibitor	/	否
HY-138561	EFdA-TP	Inhibitor	/	否
HY-143869	HPK1-IN-28	Inhibitor	/	否
HY-143870	HPK1-IN-29	Inhibitor	/	否
HY-148412	Monarsen	Inhibitor	/	否
HY-156154	Caspase-3 activator 1	Inducer	/	否
HY-N2983	Cajanin	Inhibitor	/	否
HY-RS03591	DCT Human Pre-designed siRNA Set A		/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	DCT	VGNC	VGNC:39814
Macaca mulatta	DCT	VGNC	VGNC:71749
Bos taurus	DCT	VGNC	VGNC:27926
Rattus norvegicus	DCT	RGD	RGD:1564975
Mus musculus	DCT	MGD	MGI:102563
Felis catus	DCT	VGNC	VGNC:61377
Others	DCT	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。沪(浦)应急管危经许[2021]201709(QFYS)	站点地图隐私声明
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.	沪ICP备15051369号-4

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。沪(浦)应急管危经许[2021]201709(QFYS)

站点地图隐私声明

DCT - dopachrome tautomerase Gene

关于 DCT

功能概要

DCT 基因产物(7)

DCT 蛋白结构

重组 DCT 蛋白

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

DCT - dopachrome tautomerase Gene

关于 DCT

功能概要

DCT 基因产物(7)

DCT 蛋白结构

重组 DCT 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z