1. Anti-infection Cell Cycle/DNA Damage
  2. Reverse Transcriptase DNA/RNA Synthesis HIV
  3. EFdA-TP

EFdA-TP 是一种有效的核苷逆转录酶 (RT) 抑制剂。EFdA-TP 作为有效的立即或延迟链终止剂 (ICT 或 DCT) 抑制 RT 催化的 DNA 合成。EFdA-TP 通过多种机制抑制 HIV-1 RT。

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EFdA-TP Chemical Structure

EFdA-TP Chemical Structure

CAS No. : 950913-56-1

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EFdA-TP is a potent nucleoside reverse transcriptase (RT) inhibitor. EFdA-TP inhibits RT-catalyzed DNA synthesis as an effective immediate or delayed chain terminator (ICT or DCT). EFdA-TP inhibits HIV-1 RT with multiple mechanisms[1].

IC50 & Target[1]

HIV-1

 

体外研究
(In Vitro)

EFdA-TP (0.05-10 μM; for 15 min) inhibits RT-catalyzed DNA synthesis as an ICT or DCT[1].
EFdA-TP can block RT as a translocation-defective RT inhibitor that dramatically slows DNA synthesis, acting as a de facto immediate chain terminator. EFdA-TP can function as a delayed chain terminator, allowing incorporation of an additional dNTP before blocking DNA synthesis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

533.19

Formula

C12H15FN5O12P3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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  • Do most proteins show cross-species activity?

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产品名称:
EFdA-TP
目录号:
HY-138561
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